AI Article Synopsis
- Traditional prognostication of colorectal cancer (CRC) relies on TNM staging, but survival patterns indicate that other factors also influence outcomes.
- Key histological and molecular features, such as tumor budding and biomarkers like MSI and KRAS, are being identified as crucial for improving prognosis and treatment strategies.
- This study offers an in-depth look at how these features and biomarkers can guide risk stratification and optimize CRC treatment based on current research evidence.
Article Abstract
The prognostication of colorectal cancer (CRC) has traditionally relied on staging as defined by the Union for International Cancer Control (UICC) and American Joint Committee on Cancer (AJCC) TNM staging classifications. However, clinically, there appears to be differences in survival patterns independent of stage, suggesting a complex interaction of stage, pathological features, and biomarkers playing a role in guiding prognosis, risk stratification, and guiding neoadjuvant and adjuvant therapies. Histological features such as tumour budding, perineural invasion, apical lymph node involvement, lymph node yield, lymph node ratio, and molecular features such as MSI, KRAS, BRAF, and CDX2 may assist in prognostication and optimising adjuvant treatment. This study provides a comprehensive review of the pathological features and biomarkers that are important in the prognostication and treatment of CRC. We review the importance of pathological features and biomarkers that may be important in colorectal cancer based on the current evidence in the literature.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700531 | PMC |
| http://dx.doi.org/10.3390/curroncol28060447 | DOI Listing |
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