Follow-up analysis and histopathological study of gastric mucosa in patients with infection.

Objective: To investigate the histomorphological characteristics of the gastric mucosa and the prognosis in patients with infection.

Methods: Progressive damage to the gastric mucosa was examined by immunohistochemistry in 2294 patients with infection and follow-up information was analyzed.

Results: initially colonized the mucus layer covered by the gastric mucosa epithelium, then selectively adhered to and destroyed the surface mucus cells causing intra-gastric and extra-gastric lesions. Gastric mucosal damage induced by was divided into five stages according to the depth of invasion and degree of lesion deterioration: mucilaginous, surface mucocellular, lamina propria lesion, mucosal atrophy, and intraepithelial neoplasia stages. Morphological follow-up analysis revealed no significant difference in 6-month curative effects between stage I and stage II, but significant differences were found between stages II and III, stages III and IV, and between stages IV and stage V, respectively.

Conclusions: This novel staging strategy may be a valuable tool for diagnosing and predicting the results of gastric mucosal damage induced by infection.