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Viability of Plasmodium falciparum parasites in human plasma under different storage conditions.
Vox Sang
December 2024
Office of Blood Research and Review, Center for Biologics Evaluation and Review, Food and Drug Administration, Silver Spring, Maryland, USA.
Background And Objectives: Malaria risk deferral policies are important for mitigating the risk of transfusion-transmitted malaria and apply to all transfusable components, including plasma. While donors of plasma components are deferred for malaria risk in the United States, the viability of intraerythrocytic Plasmodium falciparum parasites present in human plasma components stored under different temperatures and durations has not been previously reported.
Materials And Methods: We spiked human plasma with a low level of ring-stage P.
Background: Despite saving a vast number of lives through blood transfusions, transfusion-transmitted infections (TTIs) still threaten the lives of people needing blood transfusion. Hence, screening blood donors and reviewing the prevalence of TTIs amongst blood donors might show the impact of these infections among our people. The aim of this study was to evaluate the prevalence rates of transfusion-transmitted infections among blood donors in Makkah as foundation for providing harmless blood transfusion in Makkah, Saudi Arabia.
View Article and Find Full Text PDFLaboratory detection of donors implicated in transfusion-transmitted malaria.
Transfusion
December 2024
Medical Affairs - Donor Screening, Roche Diagnostics Solutions, Pleasanton, California, USA.
Article Synopsis
- Transfusion-transmitted malaria (TTM) is uncommon but can be deadly, prompting a review of cases in non-endemic regions since 2010 to evaluate the effectiveness of testing methods.
- The study identified 12 TTM cases and one transmission via bone marrow transplant, with PCR tests detecting Plasmodium in most donors, while antibody tests showed lower sensitivity.
- The review suggests that newer ribosomal RNA-based molecular screening methods could significantly improve detection sensitivity for Plasmodium, potentially reducing TTM risks.
Estimated Plasmodium 18S ribosomal RNA prevalence in asymptomatic blood donors from three African countries.
Vox Sang
October 2024
Infectious Disease Consultant, North Potomac, Maryland, USA.
Article Synopsis
- The WHO African Region is significantly impacted by malaria, contributing to 94% of global cases, prompting research on detecting Plasmodium RNA in blood donors from Cameroon, Madagascar, and Mali.
- Testing involved analyzing whole blood samples using a specialized assay to identify reactive results, with findings revealing varying rates of Plasmodium repeat reactivity across the countries.
- The study concluded that detecting Plasmodium RNA and related antibodies can enhance safety measures in blood donations and help tackle malaria risks effectively.
Response Patterns and Behavior of Seropositive Blood Donors: A Comprehensive Analysis.
Cureus
August 2024
Transfusion Medicine, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai, IND.
Article Synopsis
- Blood transfusion services are essential in healthcare, focusing on the identification of seropositive blood donors to enhance the safety of transfusion practices.
- A study spanning 24 months at a southern Indian hospital found that out of 8,276 donations, 117 (1.41%) tested reactive for transfusion-transmitted infections, with hepatitis B being the most prevalent at 0.61%.
- It was revealed that 70% of reactive donors were contacted post-donation, but challenges like inaccurate addresses hindered follow-up, emphasizing the need for accurate information from donors and the importance of post-donation counseling.
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