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Vistla: identifying influence paths with information theory.
Bioinformatics
January 2025
Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw, Warsaw, 02-106, Poland.
Motivation: It is a challenging task to decipher the mechanisms of a complex system from observational data; especially in biology, where systems are sophisticated, measurements coarse and multi-modality is a common trait. The typical approaches of inferring a network of relationships between system's components struggle with the quality and feasibility of estimation, as well as with the interpretability of the results they yield.Said issues can be avoided, however, when dealing with a simpler problem of tracking only the influence paths, defined as circuits relying the information of an experimental perturbation as it spreads through the system.
View Article and Find Full Text PDFEffectiveness of Mobile Health-Based Gamification Interventions for Improving Physical Activity in Individuals With Cardiovascular Diseases: Systematic Review and Meta-Analysis of Randomized Controlled Trials.
JMIR Serious Games
January 2025
School of Nursing, Jilin University, Changchun, China.
Background: Gamification refers to using game design elements in nongame contexts. Promoting physical activity (PA) through gamification is a novel and promising avenue for improving lifestyles and mitigating the advancement of cardiovascular diseases (CVDs). However, evidence of its effectiveness remains mixed.
View Article and Find Full Text PDFBioequivalence Design With Sampling Distribution Segments.
Stat Med
February 2025
Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, Ontario, Canada.
In bioequivalence design, power analyses dictate how much data must be collected to detect the absence of clinically important effects. Power is computed as a tail probability in the sampling distribution of the pertinent test statistics. When these test statistics cannot be constructed from pivotal quantities, their sampling distributions are approximated via repetitive, time-intensive computer simulation.
View Article and Find Full Text PDFMolecular Characterization of Colistin- and Carbapenem-Resistant : Mutations and Clonal Diversity in Pediatric Intensive Care Isolates.
Microb Drug Resist
January 2025
Department of Medical Microbiology, Ankara University School of Medicine, Ankara, Türkiye.
Colistin- and carbapenem-resistant (ColR CrKp) cause important health problems in pediatric intensive care units (PICUs) due to its ability to harbor multiple resistance genes and spread of high-risk clones. In this study, molecular epidemiological characteristics, transferable resistance genes, and alterations of ColR CrKp isolated from PICU were investigated. Isolates were identified by MALDI-TOF MS, and antimicrobial susceptibility tests were performed using disk diffusion method, gradient strip test, and broth microdilution method.
View Article and Find Full Text PDFExploring Future Pandemic Preparedness Through the Development of Preventive Vaccine Platforms and the Key Roles of International Organizations in a Global Health Crisis.
Vaccines (Basel)
January 2025
Pharmaceutical Regulatory Affairs, Department of Pharmaceutical Industry, Graduate School, Chung-Ang University, Seoul 06974, Republic of Korea.
The emergence of more than 40 new infectious diseases since the 1980s has emerged as a serious global health concern, many of which are zoonotic. In response, many international organizations, including the US Centers for Disease Control and Prevention (CDC), the World Health Organization (WHO), and the European Center for Disease Prevention and Control (ECDC), have developed strategies to combat these health threats. The need for rapid vaccine development has been highlighted by Coronavirus disease 2019 (COVID-19), and mRNA technology has shown promise as a platform.
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