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| http://dx.doi.org/10.1007/s12630-021-02159-z | DOI Listing |
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Evolution in the Surgical Management of Gastric Cancer Peritoneal Metastases.
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December 2024
Department of Surgery, Division of Surgical Oncology, NYU Langone Health, NYU Grossman Long Island School of Medicine, Mineola, NY 11501, USA.
Despite therapeutic treatments and the growing utilization of multimodal therapies, gastric cancer (GC) remains a highly aggressive malignancy with high mortality worldwide. Much of the complexity in treating GC is due to the high incidence of peritoneal metastasis (PM), with mean overall survival typically ranging from 4 to 10 months. With current systemic therapy, targeted therapies, and immunotherapies continuing to remain ineffective for GC/PM, there has been a significant growing interest in intraperitoneal (IP) therapies for the treatment of GC/PM.
View Article and Find Full Text PDFEngineered Phage Enables Efficient Control of Gene Expression upon Infection of the Host Cell.
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December 2024
CAS Key Laboratory for Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Recently, we developed a spatial phage-assisted continuous evolution (SPACE) system. This system utilizes chemotaxis coupled with the growth of motile bacteria during their spatial range expansion in soft agar to provide fresh host cells for iterative phage infection and selection pressure for preserving evolved genes of interest carried by phage mutants. Controllable mutagenesis activated only in a subpopulation of the migrating cells is essential in this system to efficiently generate mutated progeny phages from which desired individuals are selected during the directed evolution process.
View Article and Find Full Text PDFA Brief History of Ferritin, an Ancient and Versatile Protein.
Int J Mol Sci
December 2024
Department of Chemistry, State University of New York at Potsdam, Potsdam, NY 13676, USA.
Ferritin, a highly conserved iron storage protein, is among the earliest proteins that have been purified, named, and characterized due to its unique properties that continue to captivate researchers. Ferritin is composed of 24 subunits that form an almost spherical shell delimiting a cavity where thousands of iron atoms can be stored in a nontoxic ferric form, thereby preventing cytosolic iron from catalyzing oxidative stress. Mitochondrial and extracellular ferritin have also been described and characterized, with the latter being associated with several signaling functions.
View Article and Find Full Text PDFExperiment and Simulation Study on the Crashworthiness of Markforged 3D-Printed Carbon/Kevlar Hybrid Continuous Fiber Composite Honeycomb Structures.
Materials (Basel)
January 2025
Key Laboratory of Testing Technology for Manufacturing Process of Ministry of Education, Southwest University of Science and Technology, Mianyang 621010, China.
Article Synopsis
- Fiber hybridization helps address brittle fractures in composite honeycombs, but different fiber interactions create complex failure mechanisms.
- Researchers 3D-printed honeycomb composites using carbon and Kevlar fibers to study their structural failure through experiments and simulations.
- Results showed that carbon/Kevlar composites had the best energy absorption and cost-effectiveness, while CFRP had the highest load capacity; the presence of Kevlar led to ductile failure, contrasting with the brittle failure seen in Onyx honeycombs.
Artificial intelligence and assisted reproductive technology: A comprehensive systematic review.
Taiwan J Obstet Gynecol
January 2025
Division of Reproductive Medicine, Department of Obstetrics and Gynecology, Taipei Medical University Hospital, Taipei, Taiwan; Department of Obstetrics and Gynecology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address:
The objective of this review is to evaluate the contributions of Artificial Intelligence (AI) to Assisted Reproductive Technologies (ART), focusing on its role in enhancing the processes and outcomes of fertility treatments. This study analyzed 48 relevant articles to assess the impact of AI on various aspects of ART, including treatment efficacy, process optimization, and outcome prediction. The effectiveness of different machine learning paradigms-supervised, unsupervised, and reinforcement learning-in improving ART-related procedures was particularly examined.
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