AI Article Synopsis

  • Delocalization of ZO-1 from tight junctions is crucial for the plasticity of epithelial cells during tumor progression.
  • Increased levels of ZO-1 in the cytoplasm and nucleus influence the secretion of pro-inflammatory chemokines and aid in the recruitment of immune cells.
  • A correlation exists between higher densities of specific immune cells in lung tumors and cyto-nuclear expression of ZO-1, suggesting that this expression may facilitate tumor progression by altering immune cell dynamics.

Article Abstract

Delocalization of zonula occludens-1 (ZO-1) from tight junctions plays a substantial role in epithelial cell plasticity observed during tumor progression. , we reported an impact of ZO-1 cyto-nuclear content in modulating the secretion of several pro-inflammatory chemokines. , we demonstrated that it promotes the recruitment of immune cells in mouse ear sponge assays. Examining lung cancers, we showed that a high density of CD8 cytotoxic T cells and Foxp3 immunosuppressive regulatory T cells in the tumor microenvironment correlated with a cyto-nuclear expression of ZO-1. Taken together, our results support that, by affecting tumor cell secretome, the cyto-nuclear ZO-1 pool may recruit immune cells, which could be permissive for tumor progression.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8685499PMC
http://dx.doi.org/10.3389/fcell.2021.749364DOI Listing

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