LncRNA PVT1 promotes tumorigenesis of glioblastoma by recruiting COPS5 to deubiquitinate and stabilize TRIM24.

Mol Ther Nucleic Acids

Department of Neurosurgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.

Published: March 2022

LncRNA has been implicated in numerous pathophysiological processes and diseases, especially cancers. However, the role and mechanism of in the tumorigenesis of glioblastoma remain unclear. We investigated the alteration of and its key functions in glioblastoma. was upregulated and associated with poor prognosis in glioblastoma. We demonstrated that silencing suppressed cell proliferation, colony formation, and orthotopic xenograft tumor growth. Mechanistic investigations found that interacted with TRIM24 directly and increased its protein stability. recruited COPS5 to deubiquitinate TRIM24; reciprocally, depletion impaired the interaction between COPS5 and TRIM24, resulting in decreased expression of TRIM24. , TRIM24, and COPS5 coordinately contributed to the activation of STAT3 signaling and malignant phenotype of glioblastoma. Collectively, this study elucidates the essential role of in the tumorigenesis of glioblastoma, which provides candidacy therapeutic target for glioblastoma treatment.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8649109PMC
http://dx.doi.org/10.1016/j.omtn.2021.11.012DOI Listing

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