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Long-term reanalysis, future scenarios and impacts of nitrogen deposition on northern European ecosystems including the Baltic Sea and the Scandinavian Mountains.
Sci Total Environ
March 2025
Swedish Meteorological and Hydrological Institute, SE-60176 Norrköping, Sweden.
This study illustrates how a temporally consistent deposition reanalysis can be used 1/ as input data to ecosystem impact assessments, 2/ to understand past trends, and 3/ for validation of decadal to century-scale model scenarios. We have constructed a multi-decadal (1983-2013) reanalysis of nitrogen deposition (N) to northern Europe, including the Baltic Sea and the Scandinavian Mountains, using a combination of observations and modelling. We expanded the period with an operational annual reanalysis applying chemistry transport modelling, resulting in a fused dataset using the MATCH Sweden system for the period 1983-2021, and compared this to multi-century model scenarios of nitrogen deposition.
View Article and Find Full Text PDFIncidental High-Grade Sellar Solitary Fibrous Tumor Mimicking Non-Functioning Pituitary Adenoma: A Case Report and Literature Review.
Am J Case Rep
March 2025
Department of Radiation Oncology, Emory University School of Medicine, Atlanta, GA, USA.
BACKGROUND Sellar solitary fibrous tumors (SFT) are uncommon brain tumors belonging to the fibroblastic and myofibroblastic category of the 2021 World Health Organization (WHO) Classification of Central Nervous System (CNS) Tumors. Twenty-two instances of sellar WHO grade II and III SFT (SFT II/III) have been reported since 1983. SFTs II/III clinical and imaging findings resemble non-functioning pituitary adenomas (NFPAs).
View Article and Find Full Text PDFDietary and related data collected during pregnancy in the Avon Longitudinal Study of Parents and Children (ALSPAC).
Wellcome Open Res
February 2025
Centre for Academic Child Health, Canynge Hall, University of Bristol Medical School, Bristol, England, UK.
The Avon Longitudinal Study of Parents and Children (ALSPAC) is a longitudinal birth cohort study based in the south-west of the UK. Pregnant women resident in and around the city of Bristol with expected delivery dates between 1 April 1991 and 31 December 1992 were invited to take part. The initial number of pregnancies enrolled was 14,541.
View Article and Find Full Text PDFTargeting the retinoid signaling pathway with YCT-529 for effective and reversible oral contraception in mice and primates.
Commun Med (Lond)
March 2025
Department of Medicinal Chemistry and Institute for Therapeutics Discovery and Development, College of Pharmacy, University of Minnesota, 717 Delaware Street SE, Minneapolis, MN, 55414, USA.
Background: The retinoic acid receptor alpha (Rarα) has been validated as a male contraceptive target by genetic knockouts resulting in male sterility. The effects on spermatogenesis in the absence of RARα resemble the loss of RAR signaling in vitamin A deficiency, and the mice are otherwise normal. The effects on spermatogenesis in animals treated orally with the dual RARα/RARγ antagonist BMS-189453 closely phenocopies the absence of RARα function.
View Article and Find Full Text PDFInflammatory marker cut-off points and prognosis in incurable cancer: validation study.
BMJ Support Palliat Care
March 2025
Palliative Care Unit, National Cancer Institute, Rio de Janeiro, RJ, Brazil.
Objectives: The study aimed to determine and validate cut-off points for selected inflammatory markers to predict 30-day, 60-day and 90-day survival in patients with incurable cancer exclusively receiving palliative care.
Methods: Prospective cohort study with patients referred to the palliative care unit of a national reference centre for cancer in Brazil. The sample (n=2098) was randomised into development (n=1049) and validation (n=1049) groups.
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