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Correlation of ACE2 with RAS components after Losartan treatment in light of COVID-19. | LitMetric

Correlation of ACE2 with RAS components after Losartan treatment in light of COVID-19.

Sci Rep

Division of RI Application, Korea Institute of Radiological and Medical Sciences, 75 Nowon-Gil, Gongneung-Dong, Nowon-Gu, Seoul, 01812, Korea.

Published: December 2021

AI Article Synopsis

Article Abstract

Angiotensin-converting enzyme 2 (ACE2) is an important factor in coronavirus disease (COVID-19) interactions. Losartan (LOS) belongs to the angiotensin receptor blocker (ARB) family. Additionally, the protective role of ACE2 restored by LOS has been suggested and clinically examined in the treatment of COVID-19 patients. Furthermore, clinical trials with LOS have been conducted. However, the mechanism through which LOS enhances ACE2 expression remains unclear. In addition, the response of ACE2 to LOS differs among patients. Our LOS-treated patient data revealed a correlated mechanism of ACE2 with components of the renin-angiotensinogen system. We observed a significant positive regulation of MAS1 and ACE2 expression. In the context of LOS treatment of COVID-19, ACE2 expression could depend on LOS regulated MAS1. Thus, MAS1 expression could predict the COVID-19 treatment response of LOS.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8695574PMC
http://dx.doi.org/10.1038/s41598-021-03921-5DOI Listing

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