AI Article Synopsis

  • A study aimed to compare the effectiveness of two diagnostic methods, 5-ALA-mediated photodynamic diagnosis (PDD) and narrow-band imaging (NBI), for detecting bladder cancer during transurethral resection of bladder tumors (TURBT).
  • In the study, 114 patients were given 5-ALA and their bladders were inspected using white light (WL), PDD, and NBI, with results compared to pathology outcomes.
  • The findings revealed that PDD had a higher sensitivity for detecting cancerous lesions than NBI (89.6% vs. 76.2%), suggesting that adding PDD to conventional methods can improve cancer detection rates significantly, especially for carcinoma in situ (CIS

Article Abstract

Background: To compare 5-aminolevulinic acid (5-ALA)-mediated photodynamic diagnosis (PDD) with narrow-band imaging (NBI) for cancer detection during transurethral resection of bladder tumour (TURBT).

Methods: Between June 2018 and October 2020, 114 patients and 282 lesions were included in the analysis. Patients were orally administered 5-ALA (20 mg/kg) 2 h before TURBT. The bladder was inspected with white light (WL), PDD, and NBI for each patient, and all areas positive by at least one method were resected or biopsied. The imaging data were then compared to the pathology results.

Results: The sensitivities of WL, PDD, and NBI for detecting urothelial carcinoma were 88.1%, 89.6%, and 76.2%, respectively. The specificity, positive predictive value, and negative predictive value for detecting urothelial carcinoma were 47.5%, 80.9%, and 61.3%, respectively, for WL; 22.5%, 74.5%, and 46.2%, respectively, for PDD; and 46.3%, 78.2%, and 43.5%, respectively, for NBI. PDD was significantly more sensitive than NBI for all lesions (p < 0.001) and carcinoma in situ (CIS) lesions (94.6% vs. 54.1%, p < 0.001).

Conclusions: PDD can increase the detection rate of bladder cancer, compared to NBI, by greater than 10%. Therefore, 100% of CIS lesions can be detected by adding PDD to WL.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8693495PMC
http://dx.doi.org/10.1186/s12894-021-00946-wDOI Listing

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