AI Article Synopsis
- The study investigates the role of adipokines in the follicular fluid to predict the success of in vitro fertilization (IVF) in women with varying body weights.
- Results show that the leptin/ghrelin ratio in pregnant women during IVF is significantly higher than in non-pregnant women with normal body weight, indicating its potential as a predictor of IVF outcomes.
- For women with increased body weight, no adipokine measurements showed predictive value for IVF success, suggesting that the leptin/ghrelin ratio is a more reliable indicator for those with normal body weight.
Article Abstract
Introduction: Adipokines are involved in the regulation of the female reproductive system. The purpose was to study the possibility of using adipokines levels in the follicular fluid to predict IVF efficiency.
Materials And Methods: Four groups of women were studied: pregnant during IVF, with normal (PN, = 9) and increased (BMI > 25 kg/m) body weight (BW) (PI, = 7), and nonpregnant during IVF, with normal (nPN, = 16) and increased BW (nPI, = 21).
Results: In PN group, leptin level was higher than in nPN group ( < .05). In the PI and nPI groups, it did not differ, but was higher than in women with normal BW. In PN group, ghrelin level was lower than in nPN group ( < .05), while in the PI and nPI groups it was comparable. The leptin/ghrelin ratio in PN group was higher than in nPN group (18.10 ± 3.38 vs. 3.93 ± 0.60, < .05), but lower than in the PI (31.70 ± 15.38) and nPI (24.30 ± 3.45) groups. The leptin/adiponectin ratio in PN group was also higher than in nPN group (6.97 ± 0.64 vs. 2.95 ± 0.39, < .05), but lower than in the PI (13.60 ± 1.59) and nPI (10.86 ± 0.87) groups. Adiponectin levels differed only between the nPN and nPI groups. In women with normal BW, odds ratio showed that the leptin/ghrelin ratio has the greatest prognostic value for predicting the success of IVF outcomes (OR: 29.53; CI: 1.53-570.83, =.025) among other indicators. In women with increased BW, none of the indicators had predictive value.
Conclusion: The follicular leptin/ghrelin ratio is a suitable indicator for predicting IVF outcomes in women with normal BW.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/09513590.2021.2006512 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The impact of uterine cavity structural features on reproductive outcomes in T-shaped uterine malformation.
J Ultrasound
December 2024
Department of Ultrasound in Obstetrics, Gynecology, and Fetal Medicine, Yerevan State Medical University after Mkhitar Heratsi, 2 Koryun St, 0025, Yerevan, Armenia.
Objectives: Despite advancements in modern medicine, the effectiveness of in vitro fertilization (IVF) remains low. This study aimed to assess the impact of specific features of T-shaped uterine cavity malformation and its intermediate forms on reproductive function and the effectiveness of assisted reproductive technology (ART), particularly on IVF results and pregnancy outcomes.
Methods: A prospective cohort study included 388 somatically healthy patients undergoing 3D ultrasound (US) examination of the uterine cavity before embryonic transfer for IVF treatment.
Clinical validation and experiences of the microfluidics sperm selection device ZyMōt™ for standard IVF.
JBRA Assist Reprod
December 2024
Örebro University Department of Obstetrics and Gynecology Faculty of Medicine and Health Örebro Sweden Department of Obstetrics and Gynecology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Objective: Clinical validation of sperm selection device ZyMōt™ for standard IVF.
Methods: The pre-clinical validation of ZyMōt™ included several steps. First, split semen preparation compared density gradient centrifugation (DGC) to ZyMōt™ with primary outcome fraction and absolute number of progressive motile sperm.
Case report: A successful live birth after fertilization and embryo transfer in a patient with endometrial cancer who was treated conservatively.
Front Oncol
December 2024
Department of Obstetrics and Gynecology, School of Medicine, Nankai University, Tianjin, China.
Objective: To describe a patient conceiving with fertilization and embryo transfer(IVF-ET) after conservative treatment of early stage endometrial cancer.
Patient: A 31-year-old multiparous woman diagnosed with highly-differentiated (G1) endometrial adenocarcinoma (grade IA).
Interventions: After four courses of conservative treatment each followed by hysteroscopic biopsy and endometrial curettage,assisted reproductive technology was performed.
Perinatal outcomes of progesterone in natural frozen-thawed embryo transfer pregnancies: insights from two randomized controlled trials.
Fertil Steril
December 2024
Department of Women's and Children's Health, Uppsala University, 751 85 Uppsala, Sweden; Reproduction Center, Uppsala University Hospital, 751 85 Uppsala, Sweden; Division of Obstetrics and Gynaecology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, 171 77 Stockholm, Sweden.
Objective: To explore whether progesterone supplementation during luteal phase and early pregnancy following a natural frozen-thawed embryo transfer cycle (NC-FET) affects perinatal outcomes.
Design: A secondary data analysis study based on two randomized control trials taking place during 2008-2011 and 2013-2018 at two university hospitals in Sweden.
Subjects: A total of 923 women undergoing a natural FET cycle.
Subclinical/overt hypothyroidism may be associated with diminished ovarian reserve in infertile women independent of thyroid autoimmunity.
Front Endocrinol (Lausanne)
December 2024
Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, Shenzhen Zhongshan Institute for Reproductive Medicine and Genetics, Shenzhen, China.
Objective: To investigate the association between thyroid dysfunction or thyroid autoimmunity (TAI) and diminished ovarian reserve (DOR).
Methods: A total of 2,867 women undergoing their first fertilization (IVF) cycle at Shenzhen Zhongshan Obstetrics & Gynecology Hospital between January 1, 2013 and June 30, 2021, were enrolled in this study. The participants had documented thyroid and ovarian reserve metrics.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!