AI Article Synopsis
- The study aimed to assess how effective controlled ovarian stimulation is in various menstrual cycle phases for cancer patients who want to preserve their reproductive materials before treatment.
- A total of 140 cancer patients were given ovarian stimulation in two different phases: the standard protocol in the follicular phase and a random-start protocol during the luteal phase.
- Results showed no significant differences in the number of oocytes retrieved between the two groups, indicating that both stimulation protocols are equally effective, paving the way for tailored reproductive strategies in cancer care and Assisted Reproductive Technology (ART).
Article Abstract
Objective: The purpose of the study was to evaluate the effectiveness of controlled ovarian stimulation in different phases of the menstrual cycle in cancer patients seeking for the preservation of reproductive material before gonadotoxic therapy.
Methods: A total of 140 patients with oncological diseases underwent ovarian stimulation in the standard protocol with GnRH antagonists in the follicular phase of the cycle ( = 68) and in the random-start protocol in the luteal phase of the menstrual cycle without prescribing GnRH antagonists ( = 72).
Results: All patients included in the study were comparable in age and AMH level. There were no differences in the mean number of oocytes retrieved in the follicular phase group, and luteal phase group. Similarly, no significant differences were observed in the number of M II oocytes.
Conclusions: The results of the study demonstrate the equal effectiveness of stimulation protocols in different phases of the menstrual cycle, which allows us to develop a personalized approach to the implementation of reproductive function both in cancer patients and in the routine practice of ART.
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| http://dx.doi.org/10.1080/09513590.2021.2006458 | DOI Listing |
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