Context.—: Basal vacuolization (BV) in renal tubules is a histopathologic hallmark of advanced ketoacidosis that enables us to retrospectively diagnose these cases.
Objective.—: To clarify the pathologic background and serologic findings of ketoacidosis with BV, and to reveal the pathologic findings by each pathologic background.
Design.—: We examined 664 serial autopsy cases. A systemic histopathologic examination and measurement of serum β-hydroxybutyrate concentration were performed for the cases with BV. The extent of steatosis and fibrosis in the organs and the degree of coronary artery stenosis were semiquantitatively investigated. Immunohistochemistry for adipophilin was also performed to analyze its usefulness for the pathologic diagnosis.
Results.—: Basal vacuolization was found in 16 cases, all of which showed a pathologic serum β-hydroxybutyrate concentration. The main background of ketoacidosis was considered as alcohol abuse in 6 cases, diabetes in 5, malnutrition in 3, and hypothermia and infection in 1 case each. Severe hepatic fibrosis was observed only in the alcohol-abuser group. Moreover, cardiac steatosis was more severe in patients with possible alcohol abuse than in those with other causes. Immunohistochemistry for adipophilin showed immunoreactivity consistent with BV in 13 of 16 cases. There was no correlation between β-hydroxybutyrate concentration and either the postmortem or storage interval.
Conclusions.—: Basal vacuolization may be a useful finding for detecting ketoacidosis cases in a postmortem investigation. Serum β-hydroxybutyrate was a stable and reliable compound for the definitive diagnosis of ketoacidosis in such cases. The present study showed that pathologic changes in some organs may vary by each pathologic background of ketoacidosis with BV.
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http://dx.doi.org/10.5858/arpa.2021-0226-OA | DOI Listing |
Wiad Lek
December 2024
MUNICIPAL ENTERPRISE "CENTRAL CITY HOSPITAL OF CHERVONOGRAD CITY COUNCIL ", CHERVONOGRAD, UKRAINE.
Objective: Aim: Installation the changes of the microstructural rearrangement of the layers of the rat cornea at the end of the second week of experimental streptozotocin- induced diabetes.
Patients And Methods: Materials and Methods: The research was conducted on 15 sexually mature, outbred white male rats, weighing 120-130 g. Two groups of animals were used in the work: the first group with developing diabetes (2 weeks after administration of streptozotocin); the second group served as control and received injections of 0.
Front Nutr
November 2024
College of Animal Science and Technology, Northwest A&F University, Yangling, China.
Introduction: Fatty liver syndrome (FLS) is a prevalent nutritional and metabolic disease that mainly occurs in caged laying hens, causing substantial losses in the poultry industry. The study was carried out to explore the protective effect and potential mechanism of betaine on early FLS.
Methods: There were three groups: Con group (basal diet), FLS group (Dexamethasone injection + basal diet) and betaine group (Dexamethasone injection + basal diet with 8 g/kg betaine).
J Integr Plant Biol
December 2024
State Key Laboratory of Nutrient Use and Management, College of Resources and Environmental Sciences, National Academy of Agriculture Green Development, China Agricultural University, Beijing, 100193, China.
Phosphorus (P) is an essential macronutrient for plant growth and development. Vacuoles play a crucial role in inorganic phosphate (Pi) storage and remobilization in plants. However, the physiological function of vacuolar phosphate efflux transporters in plant Pi remobilization remains obscure.
View Article and Find Full Text PDFAntioxidants (Basel)
November 2024
Key Laboratory of Efficient Utilization and Processing of Marine Fishery Resources of Hainan Province, Sanya Tropical Fisheries Research Institute, Sanya 572018, China.
Curr Issues Mol Biol
November 2024
Animal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, China.
Cadmium (Cd) exposure can induce follicular atresia and laying performance reduction in hens, which is linked to autophagy within the granulosa cells. Selenium (Se) can influence autophagy and counteract Cd toxicity. This study aimed to investigate the protective effect of Se on Cd-induced follicular atresia in laying hens.
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