AI Article Synopsis
- This study evaluated the antioxidant and oxidant status, as well as the microbial and cancer-fighting properties of the wild mushroom Laeticutis cristata.
- The mushroom showed a strong antioxidant potential with a total antioxidant status (TAS) of 3.623 and a lower total oxidant status (TOS) of 27.476, indicating a favorable oxidative stress balance.
- Laeticutis cristata also exhibited significant antibacterial and antifungal activity and effectively inhibited the growth of the A549 lung cancer cell line, suggesting its potential use in pharmaceutical applications.
Article Abstract
In this study, the antioxidant status, oxidant status, antimicrobial activity, and antiproliferative activity of wild mushroom, Laeticutis cristata, were determined. Total antioxidant status (TAS) and total oxidant status (TOS) were determined using the Rel Assay TAS kit and the Rel Assay TOS kit, respectively. Antibacterial and antifungal activities were determined using the modified agar dilution method. An antiproliferative effect was determined by the MTT cell viability assay against lung cancer cell line A549. L. cristata demonstrated significant antioxidant potential, with a TAS value of 3.623 ± 0.250, TOS of 27.476 ± 0.314, and oxidative stress index of 0.765 ± 0.051. In addition, its antifungal activity was high (25 µg/mL). L. cristata was determined to have a strong antiproliferative effect against A549. As a result, it is thought that L. cristata can be used as a natural material in pharmacological designs.
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| http://dx.doi.org/10.1615/IntJMedMushrooms.2021040415 | DOI Listing |
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