AI Article Synopsis
- - The practice of measuring cerebrospinal fluid (CSF) biomarkers for diagnosing Alzheimer's disease (AD) is inconsistent across different medical centers, leading to varied interpretations of the same results.
- - A study involving 40 centers worldwide analyzed their analytical protocols and reports to create a consensus on how to interpret CSF biomarker profiles effectively.
- - The findings highlighted that while the analytical methods were largely similar, there was significant variability in how results were reported; as a result, harmonized reporting formats were established for clearer communication among laboratories.
Article Abstract
Introduction: The current practice of quantifying cerebrospinal fluid (CSF) biomarkers as an aid in the diagnosis of Alzheimer's disease (AD) varies from center to center. For a same biochemical profile, interpretation and reporting of results may differ, which can lead to misunderstandings and raises questions about the commutability of tests.
Methods: We obtained a description of (pre-)analytical protocols and sample reports from 40 centers worldwide. A consensus approach allowed us to propose harmonized comments corresponding to the different CSF biomarker profiles observed in patients.
Results: The (pre-)analytical procedures were similar between centers. There was considerable heterogeneity in cutoff definitions and report comments. We therefore identified and selected by consensus the most accurate and informative comments regarding the interpretation of CSF biomarkers in the context of AD diagnosis.
Discussion: This is the first time that harmonized reports are proposed across worldwide specialized laboratories involved in the biochemical diagnosis of AD.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9787404 | PMC |
| http://dx.doi.org/10.1002/alz.12545 | DOI Listing |
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