AI Article Synopsis
- Nummular and classical atopic dermatitis have different appearances but share some underlying characteristics; this study aimed to explore their differences and similarities in children.
- Researchers examined 10 children with nummular atopic dermatitis, 14 with classical atopic dermatitis, and 10 healthy controls, finding that nummular dermatitis occurred more in boys and less often in infants compared to classical dermatitis.
- Both types showed issues like lower skin hydration and higher moisture loss, but nummular dermatitis showed more variation in eczema patterns and more severe keratosis pilaris, suggesting that they should be treated as separate conditions with distinct therapeutic strategies.
Article Abstract
Nummular (coin-shaped) and classical (flexural) atopic dermatitis differ morphologically, but no other distinguishing features are known. The aim of this study was to determine differences and similarities of both variants in children. Detailed interviews, clinical examinations, biophysical measurements and electron microscopic analyses were performed on 10 children with nummular atopic dermatitis, 14 with classical atopic dermatitis and 10 healthy controls. Nummular atopic dermatitis affected more boys than girls and manifested less frequently within the first year of life than classical atopic dermatitis. Localization, distribution and morphology of the eczema varied more over time, and expression of keratosis pilaris was more severe in children with nummular atopic dermatitis. Both disease groups showed reduced hydration, increased transepidermal water loss and reduced intercellular lipid lamellae in lesional skin areas compared with non-lesional areas. These findings underline the separate classification of both variants. Further research is necessary to investigate the potential of diverging therapeutic approaches.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631256 | PMC |
| http://dx.doi.org/10.2340/actadv.v101.979 | DOI Listing |
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