Phenol ester activated dipeptides that are reluctant to ring-close have been cyclised with the aid of sterically shielding metallo-porphyrins avoiding unwanted intermolecular reactions. The binding of ZnTPP to the dipyridine-functionalised activating phenolic ester was studied by NMR titrations and modelling. Staudinger-mediated cyclisations in the presence of ZnTPP increased the yield of the cyclic dipeptide from 16% to 40%.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8767553 | PMC |
| http://dx.doi.org/10.1039/d1ob02309h | DOI Listing |
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