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The A-Z of age-related dermatological diseases.
Br J Community Nurs
January 2025
Freelance medical writer and journalist.
Skin ageing is an inevitable process influenced by both intrinsic and extrinsic factors. Intrinsic aging leads to thinner, drier and less elastic skin with fine wrinkles, while extrinsic factors such as sun exposure, smoking and environmental stresses amplify these changes. Photo-ageing, in particular, causes deep wrinkles, uneven pigmentation and increases the risk of skin cancers.
View Article and Find Full Text PDFEffects of antioxidants on skin hydration, inflammatory cytokines, and keratinocyte differentiation markers in a PM-exposed skin barrier-disrupted mouse model.
Int J Immunopathol Pharmacol
December 2024
Department of Dermatology, School of Medicine, Kyungpook National University, Daegu, Korea.
Given that particulate matter (PM) has an established role in inducing oxidative stress, inflammation, and skin aging, it is plausible that PM could exacerbate inflammatory skin conditions such as xerosis. Xerosis represents a significant dermatological concern among older adults within aging populations. We conducted an investigation into the efficacy of antioxidants, such as dieckol, punicalagin, epigallocatechin gallate (EGCG), and resveratrol, against PM in a skin barrier-disrupted mouse model.
View Article and Find Full Text PDFPruritus prevalence and characteristics in Care and Treatment Facility and Geriatric Outpatient Clinic patients: a cross-sectional study using a standardized pruritus questionnaires.
Postepy Dermatol Alergol
October 2024
Department of Dermatology, Pediatric Dermatology and Oncology, Medical University of Lodz, Poland.
Introduction: Chronic pruritus is one of the most common symptoms in geriatric patients. Pathogenesis of pruritus is multifactorial.
Aim: To evaluate the prevalence and characteristics of pruritus in geriatric patients and to characterise pruritus and explore its possible underlying causes.
Cutaneous Toxicities of MEK Inhibitor Use in Children: A Comparison of Binimetinib and Selumetinib.
Pediatr Dermatol
November 2024
Ronald O. Perelman Department of Dermatology, New York University Grossman School of Medicine, New York, New York, USA.
Background: Binimetinib and selumetinib are two mitogen-activated protein kinase kinase (MEK) inhibitors used to treat low-grade gliomas and plexiform neurofibromas. Cutaneous toxicities are commonly associated with MEK inhibitors; however, limited studies have examined cutaneous effects in a pediatric population or whether toxicities vary between MEK inhibitors.
Methods: We conducted an IRB-approved, single-center, retrospective review of pediatric neuro-oncology patients on binimetinib or selumetinib who presented to NYU from April 2016 through July 2022.
Nearly complete hair re-pigmentation in an older patient treated with hydroxyurea for essential thrombocytosis.
J Oncol Pharm Pract
September 2024
Lucy Curci Cancer Center, Eisenhower Health, Rancho Mirage, CA, USA.
Article Synopsis
- * A case study details a 77-year-old woman with essential thrombocytosis who, after 20 weeks on low-dose hydroxyurea, experienced an unexpected change in hair color from gray to dark brown, along with other skin changes.
- * The patient's side effect was monitored without intervention since she was pleased with the new hair color, suggesting that hydroxyurea may have both therapeutic benefits and unexpected aesthetic effects due to melanocyte activation.
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