AI Article Synopsis

  • - The study analyzed live birth rates in 17,952 female cancer patients diagnosed at 18 or older from 1952-2014, comparing them to 89,436 healthy controls to understand the impact of cancer on fertility.
  • - Results showed that 17.4% of cancer survivors had at least one live birth compared to 21.7% in healthy controls, with an overall incidence rate ratio (IRR) of 0.69, indicating lower live birth rates among cancer patients.
  • - Different cancer types had varying impacts on live birth rates, with breast cancer showing an IRR of 0.44, while patients diagnosed at older ages had the lowest IRR of 0.48, highlighting the negative

Article Abstract

Objective: To define the live birth rates in a large, population-based study of the most common reproductive-age cancers in women.

Design: Retrospective cohort study.

Setting: Population-based study.

Patients: Female cancer patients diagnosed with cancer at age 18 years old or older between 1952-2014 (n = 17,952) were compared to fertility of non-cancer controls (n = 89,436).

Interventions: Live births in cancer survivors were compared with those in healthy, age-matched controls. Cases and controls were matched in the ratio of 5:1 for birth year, birthplace (Utah, yes/no), and follow-up time in Utah.

Main Outcome Measure: Rate of at least one live birth, reported as an incidence rate ratio (IRR).

Results: Of all cancer survivors, 3,127 (17.4%) had at least 1 live birth after treatment in comparison to 19,405 healthy, age-matched controls (21.7%) with the same amount of time exposure for attempting pregnancy. Breast cancer was the most common cancer type (23.1% of patients in cohort). Compared with age-matched, healthy controls, IRR of live birth was 0.69 (95% confidence interval [CI], 0.67-0.70) for all cancer types, 0.25 (95% CI, 0.20-0.33) for leukemia, 0.40 (95% CI, 0.28-0.59) for gastrointestinal cancers, 0.44 (95% CI, 0.41-0.48) for breast cancer, 0.53 (95% CI, 0.47-0.59) for central nervous system cancers, and 0.57 (95% CI, 0.44-0.73) for soft tissue cancers. With all cancer types stratified by age at diagnosis, IRR for live births in cancer survivors aged >41 years at diagnosis was 0.48 (95% CI, 0.44-0.52); IRR was 0.64 (95% CI, 0.61-0.67) in the group aged 31-40 years and 0.71 (95% CI, 0.69-0.74) in the group aged 18-30 years after their cancer treatment.

Conclusions: Cancer and its treatment were associated with lower live birth rates when comparing women with cancer vs. age-matched, healthy controls.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8655402PMC
http://dx.doi.org/10.1016/j.xfre.2021.08.004DOI Listing

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