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| http://dx.doi.org/10.1093/af/vfab062 | DOI Listing |
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Systematic transcriptome-wide analysis and validation of tributyltin-induced differential changes in the liver with sex-specific effects.
Ecotoxicol Environ Saf
March 2025
Foshan Fetal Medicine Research Institute, Foshan Maternity and Children's Healthcare Hospital Affiliated to Guangdong Medical University, Foshan, China; Department of Obstetrics, Foshan Maternity and Children's Healthcare Hospital Affiliated to Guangdong Medical University, Foshan, Guangdong, China. Electronic address:
Background: Tributyltin (TBT), a prevalent environmental antiseptic, contaminates seafood, fish, and drinking water, posing health risks. While TBT's hepatic toxicity is well-known, its sex-specific effects on liver function remain poorly understood.
Methods: To address this gap, a comprehensive analysis was conducted utilizing the Toxicant Exposures and Responses by Genomic and Epigenomic Regulators of Transcription (TaRGET) dataset.
Optical genome and epigenome mapping of clear cell renal cell carcinoma.
NAR Cancer
March 2025
School of Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, 6997801 Tel Aviv, Israel.
Cancer cells display complex genomic aberrations that include large-scale genetic rearrangements and epigenetic modulation that are not easily captured by short-read sequencing. This study presents a novel approach for simultaneous profiling of long-range genetic and epigenetic changes in matched cancer samples, focusing on clear cell renal cell carcinoma (ccRCC). ccRCC is a common kidney cancer subtype frequently characterized by a 3p deletion and the inactivation of the von Hippel-Lindau () gene.
View Article and Find Full Text PDFMaternal epigenetic index links early neglect to later neglectful care and other psychopathological, cognitive, and bonding effects.
Clin Epigenetics
March 2025
Neurology and Neurosurgery Department, Montreal Neurological Institute, Montreal, Canada.
Background: Past experiences of maltreatment and life adversity induce DNA methylation changes in adults, but less is known about their impact on mothers' maladaptive neglectful parenting and its negative effects. We performed an epigenome-wide association study to investigate the role of DNA methylation levels in mothers with neglectful care, who were exposed to childhood maltreatment and neglect, and their current negative effects. Saliva DNA methylation was determined with the Illumina Human Methylation EPIC BeadChip v1.
View Article and Find Full Text PDFEpigenome-wide association study for dilated cardiomyopathy in left ventricular heart tissue identifies putative gene sets associated with cardiac pathology and early indicators of cardiac risk.
Clin Epigenetics
March 2025
Lee Kong Chian School of Medicine, Nanyang Technological University, Clinical Sciences Building, 11 Mandalay Road, Singapore, 308232, Singapore.
Background: Methylation changes linked to dilated cardiomyopathy (DCM) affect cardiac gene expression. We investigate DCM mechanisms regulated by CpG methylation using multi-omics and causal analyses in the largest cohort of left ventricular tissues available.
Methods: We mapped DNA methylation at ~ 850,000 CpG sites, performed array-based genotyping and conducted RNA sequencing on left ventricular tissue samples from failing and non-failing hearts across two independent DCM cohorts (discovery n = 329, replication n = 85).
DNA methylation-based analysis of leukocyte landscape in children with atopic dermatitis.
Arch Dermatol Res
March 2025
McGill University Health Centre (MUHC) Center of Excellence for Atopic Dermatitis, 1001 Bd Décarie, Montréal, Québec, H4A 3J1, Canada.
Atopic dermatitis (AD) is the most common chronic, inflammatory skin condition among the pediatric population. There is a need to better characterize the leukocytic landscape of AD for disease stratification, surveillance, and to identify therapeutic targets. We utilized a novel DNA methylation (DNAm)-based algorithm to study a publicly available, epigenome-wide DNAm dataset of pediatric AD patients and healthy subjects.
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