AI Article Synopsis
- Cerebral arteriovenous malformations (AVMs) are unusual blood vessel problems in the brain that can sometimes be treated with surgery or other methods, but they rarely go away on their own.
- A 28-year-old man who had a liver transplant experienced a seizure and was found to have a small AVM in his brain, but doctors decided to just watch it instead of treating it right away.
- Remarkably, after a year, the AVM completely disappeared, which may have happened because his liver was treated, helping to fix the blood vessel issue in his brain.
Article Abstract
Background: Cerebral arteriovenous malformations (AVMs) have historically been considered congenital lesions with treatment options including surgery, radiation therapy, and observation. Spontaneous resolution of cerebral AVMs remains an exceedingly rare event with poorly understood pathophysiology.
Materials And Methods: Herein we report a retrospective case review of a 28-year-old man with alcoholic cirrhosis who presented with a seizure 3 weeks after liver transplantation. Neuroimaging confirmed the presence of a Spetzler-Martin grade 2 AVM in the right frontal lobe. Due to the recent liver transplantation, treatment was deferred at the time of initial diagnosis and the patient was observed for a course of 1 year. Follow-up imaging 1 year later showed resolution of the AVM, confirmed by a catheter angiogram.
Conclusion: Spontaneous resolution of cerebral AVMs is a rare event. Treatment of chronic liver disease resulted in the normalization of angiogenic factors that likely led to AVM resolution. This case provides valuable insight into the vital role of angiogenesis in the natural history of AVMs.
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| http://dx.doi.org/10.1080/02688697.2021.2016621 | DOI Listing |
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