AI Article Synopsis
- Alzheimer's disease (AD) is linked to cognitive decline, and this study explores how Dihydromyricetin (DMY) can mitigate these effects in aging mice induced by d-galactose.
- Through 16 weeks of d-gal injections and DMY supplementation, the study found significant improvements in cognitive tests and brain health, with DMY enhancing antioxidant activity and decreasing harmful substances in the brain.
- DMY also helps reduce cholinergic damage by inhibiting acetylcholinesterase, suggesting its potential as a therapeutic agent in combating cognitive impairments associated with AD.
Article Abstract
Scope: Alzheimer's disease (AD) is a neurodegenerative disease with phenomena of cognitive impairments. Oxidative stress and cholinergic system dysfunction are two widely studied pathogenesis of AD. Dihydromyricetin (DMY) is a natural dihydroflavonol with many bioactivities. In this study, it is aimed to investigate the effects of DMY on cognitive impairment in d-galactose (d-gal) induced aging mice.
Methods And Results: Mice are intraperitoneally injected with d-gal for 16 weeks, and DMY is supplemented in drinking water. The results show that DMY significantly improves d-gal-induced cognitive impairments in novel object recognition and Y-maze studies. H&E and TUNEL staining show that DMY could improve histopathological changes and cell apoptosis in mice brain. DMY effectively induces the activities of catalase, superoxide dismutase and glutathione peroxidase, and reduces malondialdehyde level in mice brain and liver. Furthermore, DMY reduces cholinergic injury by inhibiting the activity of Acetylcholinesterase (AChE) in mice brain. In vitro studies show that DMY is a non-competitive inhibitor of AChE with IC50 value of 161.2 µg mL .
Conclusion: DMY alleviates the cognitive impairments in d-gal-induced aging mice partly through regulating oxidative stress and inhibition of acetylcholinesterase.
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| http://dx.doi.org/10.1002/mnfr.202101002 | DOI Listing |
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