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SARS-CoV-2 infection of human pluripotent stem cell-derived vascular cells reveals smooth muscle cells as key mediators of vascular pathology during infection.
Nat Commun
December 2024
Whitehead Institute for Biomedical Research, Cambridge, MA, 02142, USA.
Although respiratory symptoms are the most prevalent disease manifestation of infection by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), nearly 20% of hospitalized patients are at risk for thromboembolic events. This prothrombotic state is considered a key factor in the increased risk of stroke, which is observed clinically during both acute infection and long after symptoms clear. Here, we develop a model of SARS-CoV-2 infection using human-induced pluripotent stem cell-derived endothelial cells (ECs), pericytes (PCs), and smooth muscle cells (SMCs) to recapitulate the vascular pathology associated with SARS-CoV-2 exposure.
View Article and Find Full Text PDFAmericans' support for future pandemic policies: insights from a national survey.
Health Aff Sch
December 2024
The de Beaumont Foundation, Bethesda, MD 20814, United States.
The arrival of bird flu (H5N1) is a poignant reminder of the need for public health leaders to understand Americans' evolving perspectives on pandemic mitigation policies. To guide response efforts, we conducted a nationally representative opinion survey among 1017 U.S.
View Article and Find Full Text PDFNetwork characteristics of referrals for chronic disease patients: results from hierarchical medical reform in Shenzhen, China.
BMC Public Health
December 2024
Department of Hospital Group Office, Shenzhen Luohu Hospital Group Luohu People's Hospital, Shenzhen, 518001, China.
Background: The Chinese government has introduced a series of hierarchical medical policies to ensure continuity of care, but referrals remain difficult to implement effectively. This study aimed to evaluate the chronic disease referral network and explore the problems associated with the specific implementation of referrals.
Methods: This study was a repeated cross-sectional study of monthly data collected between August 2017 and December 2023 in Luohu district, Shenzhen, China.
Telehealth use in the well-child health setting. A systematic review of acceptability and effectiveness for families and practitioners.
Int J Nurs Stud Adv
June 2025
Judith Lumley Centre, School of Nursing and Midwifery, La Trobe University, Melbourne, Victoria, Australia.
Background: Universal well-child health nursing services in high-resource countries promote the health and well-being of children and families while preventing health inequities. The COVID-19 pandemic and technological advancements have led to the increased use of telehealth in this field. To enhance policies and practices, it's important to understand the acceptability and effectiveness of telehealth, as well as the barriers and enablers to its implementation, and to determine when its use is appropriate and safe.
View Article and Find Full Text PDFDiscovery and development of INNA-051, a TLR2/6 agonist for the prevention of complications resulting from viral respiratory infections.
Antiviral Res
December 2024
ENA Respiratory Pty Ltd, Melbourne, Australia. Electronic address:
Viral respiratory infection is associated with significant morbidity and mortality. The diversity of viruses implicated, coupled with their propensity for mutation, ignited an interest in host-directed antiviral therapies effective across a wide range of viral variants. Toll-like receptors (TLRs) are potential targets for the development of broad-spectrum antivirals given their central role in host immune defenses.
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