In women with very active multiple sclerosis (MS), natalizumab can be continued during pregnancy to prevent rebound disease activity. Our aim was to evaluate changes in serum natalizumab trough concentrations during pregnancy. Blood samples of 3 patients were collected before, during, and after pregnancy. Natalizumab trough concentrations gradually decreased during pregnancy. The patient with the lowest trough concentrations during the third trimester was treated with extended interval dosing (EID). After delivery, natalizumab concentrations increased to similar levels as before pregnancy. All patients remained clinically and radiologically stable. MS neurologists should be aware of decreasing natalizumab concentrations during pregnancy, especially in patients with low initial trough concentrations and patients with EID.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795211 | PMC |
| http://dx.doi.org/10.1177/13524585211052168 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effect of drinking water salinity on lactating cows' water and feed intake, milk yield, and rumen physiology.
Animal
December 2024
Department of Ruminant Science, Institute of Animal Science, Agricultural Research Organization, Rishon Lezion 7528809, Israel. Electronic address:
Use of desalinated seawater in arid and semiarid regions for domestic, industrial, and agricultural purposes is on the rise. Consequently, in those regions, drinking water offered to lactating cows has lower salinity and mineral concentrations than in the past. Although water with total dissolved solids (TDSs) of up to 1 000 ppm is considered safe for drinking, lower salinity level may affect rumen physiology, feed and water intake, or milk yield.
View Article and Find Full Text PDFPeak and Trough Concentrations of Apixaban and Rivaroxaban in Adult Patients: A Systematic Review and Meta-Analysis.
J Thromb Haemost
January 2025
Center for Quality Management of Medicines, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia. Electronic address:
Article Synopsis
- Apixaban and rivaroxaban, both factor Xa inhibitors, are used for treating conditions like venous thromboembolism and preventing strokes in atrial fibrillation patients, but their optimal concentration levels in real-world settings are not well understood.
- Researchers conducted a meta-analysis of 16 observational studies to establish average peak and trough concentrations for these medications, involving a total of 2,375 patients.
- The study found that average peak concentrations for apixaban and rivaroxaban were within expected ranges, and certain factors like age and creatinine clearance were found to influence these concentrations.
Examining Whole Blood, Total and Free Plasma Tacrolimus in Elderly Kidney Transplant Recipients.
Ther Drug Monit
February 2025
School of Pharmacy, University of Queensland, Brisbane, QLD, Australia.
Background: Therapeutic monitoring is routinely performed to ensure tacrolimus whole-blood concentrations fall within a predefined target. Despite this, patients still experience inefficacy and toxicity that could be related to variability in free (unbound) tacrolimus exposure. Therefore, the aim of this study was to compare tacrolimus-free plasma (C u ), total plasma (C p ), and whole-blood (C wb ) concentrations in adult kidney transplant recipients and to characterize tacrolimus disposition across different matrices.
View Article and Find Full Text PDFInvestigation of Teicoplanin Trough Concentrations and Safety Following High-Dose Loading in a Pediatric Population.
Ther Drug Monit
January 2025
Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Background: Therapeutic drug monitoring-informed teicoplanin dosage adjustments are recommended for safe and effective use. The authors' group previously reported that only half of children reached the recommended blood concentration range at the standard teicoplanin loading dose. It has been suggested that higher loading doses are necessary; however, the usefulness and safety of high-dose loading in pediatric patients in clinical practice are unknown.
View Article and Find Full Text PDFComparing two-sample log-linear exposure estimation with Bayesian model-informed precision dosing of tobramycin in adult patients with cystic fibrosis.
Antimicrob Agents Chemother
January 2025
InsightRX, San Francisco, California, USA.
Tobramycin dosing in patients with cystic fibrosis (CF) is challenged by its high pharmacokinetic (PK) variability and narrow therapeutic window. Doses are typically individualized using two-sample log-linear regression (LLR) to quantify the area under the concentration-time curve (AUC). Bayesian model-informed precision dosing (MIPD) may allow dose individualization with fewer samples; however, the relative performance of these methods is unknown.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!