AI Article Synopsis
- - This commentary discusses the paper by Huang et al. (2021) on exosome proteins derived from human adipose-derived stem cells (hADSCs) and emphasizes the growing interest in using mesenchymal stromal cell extracellular vesicles (MSC-EVs) for research and clinical applications.
- - The authors stress the importance of providing solid evidence for the safety and effectiveness of MSC-EV preparations as they are developed for use in humans.
- - They highlight the need for consistent isolation methods to ensure reliable and high-quality MSC-EVs that meet the standards necessary for clinical-grade manufacturing.
Article Abstract
The present paper is a commentary to 'Identification and characterization of hADSC-derived exosome proteins from different isolation methods' (Huang et al. 2021; 10.1111/jcmm.16775). Given the enthusiasm for the potential of mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs), some considerations deserve attention as they move through successive stages of research and application into humans. We herein remark the prerequisite of generating that evidence ensuring a high consistency in safety, composition and biological activity of the intended MSC-EV preparations, and the suitability of disparate isolation techniques to produce efficacious EV preparations and fulfil requirements for standardized clinical-grade biomanufacturing.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8817141 | PMC |
| http://dx.doi.org/10.1111/jcmm.17112 | DOI Listing |
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