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Three weekly versus weekly concurrent cisplatin: safety propensity score analysis on 166 head and neck cancer patients. | LitMetric

AI Article Synopsis

Article Abstract

Background: Radio-chemotherapy with CDDP is the standard for H&N squamous cell cancer. CDDP 100 mg/m/q3 is the standard; alternative schedules are used to reduce toxicity, mostly 40 mg/m/q1.

Methods: Patients were treated from 1/2010 to 1/2017 in two Radiation Oncology Centres. Propensity score analysis (PS) was retrospectively used to compare these two schedules.

Results: Patients analyzed were 166. Most (114/166) had 1w-CDDP while 52 had 3w-CDDP. In the 3w-CDDP group, patients were younger, with better performance status, smaller disease extent and a more common nodal involvement than in the 1w-CDDP. Acute toxicity was similar in the groups. Treatment compliance was lower in the w-CCDP. Overall survival before PS was better for female, for oropharyngeal disease and for 3w-CDDP group. After PS, survival was not related to the CDDP schedule.

Conclusions: 3w-CDDP remains the standard for fit patients, weekly schedule could be safely used in selected patients.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8686550PMC
http://dx.doi.org/10.1186/s13014-021-01966-4DOI Listing

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