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Emerging Resistance and Virulence Patterns in : Insights into Silver Nanoparticles as an Antimicrobial Strategy.
Antibiotics (Basel)
January 2025
The Research Institute of the University of Bucharest (ICUB), 050095 Bucharest, Romania.
Background/objectives: This study aims to characterize antibiotic resistance (AR) and virulence markers in spp. isolated from Romanian outpatients' stool samples.
Methods: In 2019, community-acquired strains were collected and identified using MALDI-TOF mass spectrometry, antibiotic susceptibility profiles have been determined with the MicroScan system, and soluble virulence factors were evaluated using specific culture media, while biofilm formation was quantified in 96-well plates.
Pilot study evaluation of the eQUANT™ system for accelerated antimicrobial susceptibility testing of gram-negative organisms directly from positive blood cultures.
Diagn Microbiol Infect Dis
December 2024
University Hospitals Cleveland Medical Center, Cleveland, OH, USA; Case Western Reserve University, Cleveland, OH, USA. Electronic address:
We describe results from a multicenter pilot study evaluating the eQUANT system for rapid generation of a standardized inoculum (0.5 McFarland equivalent) directly from blood cultures positive for target gram-negative bloodstream pathogens for same-day antimicrobial susceptibility testing (AST) by disk diffusion, MicroScan and Vitek2 methods. Out of 167 blood cultures that met study criteria (monomicrobial with one of 9 target gram-negative species), colony counts from eQUANT suspensions of 164 (98.
View Article and Find Full Text PDFPerformance evaluation of the Specific Reveal system for rapid antibiotic susceptibility testing from positive blood cultures containing Gram-negative pathogens.
J Clin Microbiol
December 2024
Wisplinghoff Laboratories, Cologne, Germany.
Rapid antimicrobial drug administration is crucial for the efficient treatment of sepsis or septic shock, but empirical therapy is limited by the increasing prevalence of multidrug-resistant bacteria. Thus, rapid and reliable antimicrobial susceptibility testing (AST) is needed to start appropriate antimicrobial drug administration as quickly as possible. In the present study, we evaluated the performance of the Reveal rapid AST system.
View Article and Find Full Text PDFArticle Synopsis
- This study conducted in Rabigh City, Saudi Arabia aimed to identify antimicrobial resistance (AMR) in common pathogenic bacteria within a healthcare facility over a six-month period.
- Out of 1,933 patient samples, 11.1% showed bacterial growth, with a higher prevalence in patients over 50 years old; the majority were Gram-negative bacteria like E. coli and K. pneumoniae.
- The findings reveal significant resistance among isolated bacteria, particularly with K. pneumoniae showing increased resistance to carbapenem antibiotics, emphasizing the need for ongoing monitoring of AMR in healthcare environments.
Performance of the LifeScale automated rapid phenotypic antimicrobial susceptibility testing on Gram-negative rods directly from positive blood cultures.
J Clin Microbiol
December 2024
UofL Healthcare System, Louisville, Kentucky, USA.
Article Synopsis
- Rapid antimicrobial susceptibility testing (rAST) from blood cultures is crucial for selecting effective antibiotics for bloodstream infections, with the LifeScale system offering a promising new approach.
- LifeScale utilizes microfluidic sensors and mechanical resonators to quickly analyze individual microbes and deliver reliable rAST results in under 5 hours, outpacing standard methods.
- Notably, LifeScale addresses challenges with polymicrobial cultures and shows strong agreement with the current standard of care, potentially allowing for quicker clinical decision-making without the need for confirmatory tests.
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