[Extracellular vesicles in the central nervous system].

Med Sci (Paris)

Univ. Lille, Inserm U1172, CHU-Lille, LilNCog - Lille neuroscience et cognition, F-59000 Lille, France.

Published: December 2021

Extracellular Vesicles (EVs) are released by a wide diversity of cells. They contain proteins, RNAs and lipids that will be exchanged between these cells. They represent therefore a major form of intercellular communication in both physiological and pathological conditions. This is particularly relevant in the nervous system where neurons and glial cells form a very dense network where billions of connections are made. In this review, the different roles played by the EVs in a healthy brain to maintain cerebral homeostasis during development, synaptic transmission or axonal myelination will be discussed. In addition, the pathological aspects of EVs presence will also be addressed. In recent years, the EVs have emerged as major players in the spread of neurodegenerative diseases, in neuroinflammation and in tumor development, although they may also be beneficial in some conditions.

Download full-text PDF

Source
http://dx.doi.org/10.1051/medsci/2021205DOI Listing

Publication Analysis

Top Keywords

[extracellular vesicles
4
vesicles central
4
central nervous
4
nervous system]
4
system] extracellular
4
extracellular vesicles
4
evs
4
vesicles evs
4
evs released
4
released wide
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!