AI Article Synopsis
- Colon extranodal marginal zone lymphoma (EMZL) is not well-studied, so researchers conducted a review of cases from their institution and the SEER database to gather more information.
- Out of the eight patients at the institution, most had stage-I disease, and initial treatments included active surveillance, polypectomy, and surgical resection, with five of six treated patients achieving complete remission.
- The SEER database showed a 10-year overall survival rate of 73.9% among 361 patients with stage-I colon EMZL, highlighting the disease's indolent nature and suggesting non-aggressive treatment strategies could be effective.
Article Abstract
Colon extranodal marginal zone lymphoma (EMZL) is poorly characterized in the literature. We performed a retrospective review of patients with colon EMZL at our institution and from the Surveillance Epidemiology and End Results (SEER) database. Eight patients were identified in our institution with majority (88%) presenting with stage-I disease. Initial management included active surveillance, polypectomy followed by surveillance, and surgical resection followed by chemotherapy. One patient with concurrent prostate carcinoma received radiation to the rectum. Initial therapy led to complete remission in five out of six treated patients with four of them maintaining remission at 88 months. SEER database identified 361 patients with stage-I colon EMZL. Overall survival for this cohort was 73.9% at 10 years with no significant difference in outcomes between treatment groups. Our single institution experience and the SEER data analysis emphasize indolent nature of colon EMZL and need for non-aggressive therapeutic approaches.
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| http://dx.doi.org/10.1080/10428194.2021.2015766 | DOI Listing |
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Article Synopsis
- Colon extranodal marginal zone lymphoma (EMZL) is not well-studied, so researchers conducted a review of cases from their institution and the SEER database to gather more information.
- Out of the eight patients at the institution, most had stage-I disease, and initial treatments included active surveillance, polypectomy, and surgical resection, with five of six treated patients achieving complete remission.
- The SEER database showed a 10-year overall survival rate of 73.9% among 361 patients with stage-I colon EMZL, highlighting the disease's indolent nature and suggesting non-aggressive treatment strategies could be effective.
Site-specific morphologic differences in extranodal marginal zone B-cell lymphomas.
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Department of Pathology, Minneapolis Veterans Affairs Medical Center, Minneapolis, Minn, USA.
Context: Lymphoepithelial lesions (LELs) are a useful diagnostic feature of extranodal marginal zone B-cell lymphoma (EMZL); however, there is scant literature comparing their frequency and morphology at various sites.
Objective: To evaluate any diagnostically useful, site-specific, morphologic patterns in EMZLs.
Design: In this retrospective review, we evaluated 136 EMZLs from different sites for LEL pattern and other pathologic differences, including CD43 coexpression and plasma cell component features.
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