The role of N6-methyladenine (mA) RNA methylation in a variety of biological processes is gradually being revealed. Here, we systematically describe the correlation between the expression pattern of mA RNA methylation regulatory factors and clinical phenotype, immunity, drug sensitivity, stem cells and prognosis in more than 10,000 samples of 33 types of cancer. The results show that there are significant differences in the expression of 20 mA RNA methylation regulatory factors in different cancers, and there was a significant correlation with the analysis indicators. In this study, the mA RNA methylation regulatory factor was found not only to potentially assist in stratifying the prognosis but also to predict or improve the sensitivity of clinical drug therapy.
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| http://dx.doi.org/10.2217/fon-2021-0788 | DOI Listing |
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