Hyperventilation is common in pulmonary arterial hypertension and may be related to autonomic imbalance. Patients underwent exercise testing and hyperoxic breathing before and after bisoprolol treatment. We found that neither beta blocker treatment nor hyperoxic breathing in patients reduced hyperventilation at rest and during exercise, although it reduced heart rate.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671678 | PMC |
http://dx.doi.org/10.1177/20458940211057890 | DOI Listing |
J Appl Physiol (1985)
December 2024
Center for Hyperbaric Medicine and Environmental Physiology, Department of Anesthesiology, Duke University School of Medicine, Durham, NC, 27710, USA.
Breathing hyperoxic gas is common in diving and accelerates fatigue after prolonged and repeated exposure. The mechanism(s) remain unknown but may be related to increased oxidants that interfere with skeletal muscle calcium trafficking or impair aerobic ATP production. To determine these possibilities, C57BL/6J mice were exposed to hyperbaric oxygen (HBO) for 4-h on three consecutive days or remained in room air.
View Article and Find Full Text PDFJ Cachexia Sarcopenia Muscle
December 2024
Klinik für Kardiologie und Pneumologie, Median Klinikum Flechtingen, Flechtingen, Germany.
Introduction: Long COVID-19 illness is a severely disabling disease with shortness of breath, weakness and fatigue as leading symptoms, resulting in poor quality of life and substantial delay in return to work. No specific respiratory therapy has been validated for patients with long COVID. The intermittent hypoxia-hyperoxia training (IHHT) is a respiratory therapeutic modality to improve exercise performance via controlled respiratory conditioning.
View Article and Find Full Text PDFExp Physiol
December 2024
Centre for Human and Applied Physiological Sciences (CHAPS), Faculty of Life Sciences and Medicine, King's College London, London, UK.
Postural fluid shifts may directly affect respiratory control via a complex interaction of baro- and chemo-reflexes, and cerebral blood flow. Few data exist concerning the steady state ventilatory responses during head-down tilt. We examined the cardiorespiratory responses during acute 50° head-down tilt (HDT) in 18 healthy subjects (mean [SD] age 27 [10] years).
View Article and Find Full Text PDFChem Biol Interact
December 2024
Department of Anesthesiology, The Ohio State University, Columbus, OH, 43210, USA; Center for Medical and Engineering Innovation, The Ohio State University, Columbus, OH, 43210, USA. Electronic address:
Hyperoxic exposure lasting days alters mitochondrial bioenergetic and dynamic functions in pulmonary cells as indices of oxygen toxicity. The aim of this study was to examine effects of short duration hyperbaric and hyperoxic exposures to induce oxygen toxicity similarly. Cultured human lung microvascular endothelial cells, human pulmonary artery endothelial cells and A549 cells were exposed to hyperoxia (∼5 % CO equivalent, balance O) under hyperbaric conditions (4.
View Article and Find Full Text PDFBMJ Paediatr Open
October 2024
Department of Neonatology, Homerton University Hospital NHS Foundation Trust, London, UK.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!