CD3T, CD4T, CD8T, and CD4T/CD8T Ratio and Quantity of T Cells in Peripheral Blood of HIV-Infected/AIDS Patients and Its Clinical Significance.

Objective: To investigate the quantity of CD4T, CD4T, CD8T, and T cells in peripheral blood of HIV-infected/AIDS patients as well as to explore the possible role of CD4/CD8 ratio and T cells in the progression of HIV/AIDS, aimed at providing evidence for the diagnosis and treatment of AIDS.

Methods: The quantity levels of CD3T cells, CD4T cells, CD8T cells, and T cells in peripheral blood of 46 HIV-infected/AIDS patients and 30 healthy controls were detected by using flow cytometry.

Results: The count of CD3T, CD4T, CD8T, and T cells ( , A/l) in the peripheral blood was 1183.64 ± 132.58, 278.39 ± 122.38, 863.13 ± 82.38, and 22.53 ± 1.74 in the experimental group as well as 1456.46 ± 124.37, 788.74 ± 189.67, 569.61 ± 46.49, and 10.96 ± 0.28 in the control group, respectively. The values of the two groups were <0.005 after the -test, revealing a statistically significant difference. The proportion of CD3T, CD4T, CD8T, and T cells in total lymphocytes in the two groups ( , %) was 71.83 ± 5.37, 13.39 ± 2.23, 62.93 ± 5.81, and 3.67 ± 0.87 in the experimental group, respectively. In the control group, the values were expressed as 66.72 ± 5.48, 42.77 ± 3.38, 31.41 ± 3.62, and 1.73 ± 0.36, respectively. After performing the -test, values in the two groups were <0.005 except CD3T, with statistically significant differences. Besides, CD4/CD8 was 0.33 ± 0.11 in the experimental group and 1.48 ± 0.29 in the control group, = 26.528, < 0.001, exhibiting a significant statistical difference.

Conclusion: HIV infection induces the activation and proliferation of CD8T and T cells, contributing to the decrease of CD4T cells, while CD8T and T cells are involved in the immune response and tissue damage after HIV infection.