AI Article Synopsis
- Metabolic disorders, particularly obesity and diabetes, are on the rise in industrialized nations, with research indicating a significant connection between gut microbiota composition and these conditions.
- An obesity-inducing diet can quickly alter gut health, enhancing gut permeability and causing microbial imbalances that lead to chronic gut inflammation and insulin resistance.
- The review explores the relationship between gut inflammation, insulin resistance, and gut microbiota, highlighting a specific butyrate-producing bacterium that may serve as a biomarker for gut issues and a potential treatment option due to its ability to produce anti-inflammatory substances.
Article Abstract
Metabolic disorders are an increasing concern in the industrialized world. Current research has shown a direct link between the composition of the gut microbiota and the pathogenesis of obesity and diabetes. In only a few weeks, an obesity-inducing diet can lead to increased gut permeability and microbial dysbiosis, which contributes to chronic inflammation in the gut and adipose tissues, and to the development of insulin resistance. In this review, we examine the interplay between gut inflammation, insulin resistance, and the gut microbiota, and discuss how some probiotic species can be used to modulate gut homeostasis. We focus primarily on , a highly abundant butyrate-producing bacterium that has been proposed both as a biomarker for the development of different gut pathologies and as a potential treatment due to its production of anti-inflammatory metabolites.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8677946 | PMC |
| http://dx.doi.org/10.3389/fphar.2021.740636 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!