Objectives: Both cognitively impaired (CI) and nonimpaired (NC) older people have challenges in performing everyday tasks. Previous skills training efforts in NC individuals have led to improvements in both functional skills and cognitive functioning. We evaluated the cognitive benefits of combining computerized cognitive training (CCT) with a computer-based functional skills assessment and training (CFSAT) program in a sample of CI and NC older adults.
Design: Randomized parallel clinical trial with two treatment conditions: up to 24 sessions of CFSAT training alone or CFSAT plus speed focused CCT.
Participants: NC (n = 62) and CI (n = 55) older adults, ranging in age from 60-86 years (M = 73.12), primarily female (90%), and ethnically diverse (21% Hispanic, 52% African American). Participants were divided based on Montreal Cognitive Assessment scores and cognitive complaints.
Setting: Three different community centers in Miami, FL.
Measurements: The Brief Assessment of Cognition, app version, was used to measure cognitive performance across six different cognitive domains before and after training.
Results: All six cognitive domains improved from baseline. Multivariate analyses found the effects of the combined CFSAT and CCT to be superior. The interaction of training condition and cognitive status was not statistically significant, indicating no global impact of cognitive status on improvements in cognition across training conditions.
Conclusions: CFSAT training was associated with cognitive benefits, particularly in CI participants. The combined intervention led to greater improvements. Consistent with results of previous studies, there is considerable evidence of cognitive plasticity in older adults, including those with CI.
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http://dx.doi.org/10.1016/j.jagp.2021.11.008 | DOI Listing |
Am J Geriatr Psychiatry
December 2024
Department of Gerontology, Faculty of Social Welfare & Health Sciences, University of Haifa, 199 Aba Khoushy Ave, Haifa, 3498838, Israel. Electronic address:
Objective: Unidentified sex differences in old-age cognition may emerge in psychometric networks, which look beyond mean scores into the unique cognitive structure of males and females. Accordingly, this study aims to examine cognition in well-functioning older males and females with psychometric network analysis.
Methods: The current cohort (N = 2,802) of community-dwelling adults (≥65 years) was derived from the Advanced Cognitive Training for Independent and Vital Elderly study.
Life Sci
January 2025
Public Health - Seattle & King County, Seattle, WA, USA; Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA, USA; Department of Epidemiology, University of Washington, Seattle, WA, USA.
This review aims to describe the neurologic post-COVID-19 conditions (PCC, also known as "long COVID"), a complex array of diagnoses that can occur following recovery from acute COVID-19. The review also includes clinical considerations for the recognition, diagnosis and management of neurologic manifestations of PCC. Cognitive impairment ("Brain Fog"), headaches, and neuropathies are specifically reviewed.
View Article and Find Full Text PDFESMO Open
January 2025
Office of Quality and Value, The University of Texas MD Anderson Cancer Center, Houston, USA.
Many patients with cancer approaching the end of life (EOL) continue to receive treatments that are unlikely to provide meaningful clinical benefit, potentially causing more harm than good. This is called overtreatment at the EOL. Overtreatment harms patients by causing side-effects, increasing health care costs, delaying important discussions about and preparation for EOL care, and occasionally accelerating death.
View Article and Find Full Text PDFTissue Cell
December 2024
Department of Food Science and Nutrition, Hallym University, Chuncheon 24252, Republic of Korea. Electronic address:
Mild cognitive impairment is a diagnostic category marked by declines in memory and cognitive function that are less severe than those observed in Alzheimer's disease. Previous studies have indicated that individuals with mild cognitive impairment have an elevated risk of progressing to Alzheimer's disease. The hippocampus is well known to play pivotal roles in memory and cognitive functions.
View Article and Find Full Text PDFEur J Paediatr Neurol
December 2024
Department of Pediatrics, Peking University People's Hospital, Beijing, China; Epilepsy Center, Peking University People's Hospital, Beijing, China. Electronic address:
Aim: Exploring the association between SETD1B variants and absence seizures (ASs).
Methods: We engaged a small cohort of four pediatric epilepsy patients with identified SETD1B variants and conducted a comprehensive review of 50 documented instances. Clinical profiles were meticulously compiled, and genetic screening was executed via trio-based whole-exome sequencing.
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