Background: As critical regulators, lncRNAs have attracted attention from researchers for diagnostic, prognostic, and therapeutic purposes in human carcinogenesis via interfering with mRNAs such as EZH2. Nevertheless, the potent roles and molecular mechanisms of these RNAs in CRC are not clearly known.
Methods: In this study, the tissue expressions of lncRNA MINCR and EZH2 mRNA between colorectal tumors and polyps were compared with the adjacent normal tissues collected from 114 Iranian patients, using real-time PCR method. Furthermore, the correlation of the expression levels of MINCR and EZH2 with other clinical parameters was evaluated.
Results: The significant overexpression of MINCR and EZH2 were observed in the CRC tissues compared to control tissues (p < 0.0001). This observation confirmed the association of these expression enhancements with the pathological stage of CRC patients.
Conclusion: Our findings revealed that the expression of MINCR significantly alters during CRC development, and it can be identified as a potential biomarker for the detection of CRC.
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| http://dx.doi.org/10.52547/ibj.26.1.64 | DOI Listing |
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Natural products and long noncoding RNA signatures in gallbladder cancer: a review focuses on pathogenesis, diagnosis, and drug resistance.
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December 2024
Department of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo, 11829, Egypt.
Article Synopsis
- Gallbladder cancer (GBC) is a highly aggressive cancer with a low survival rate, influenced significantly by long noncoding RNAs (lncRNAs) and natural products that affect cancer behaviors such as proliferation and metastasis.
- Natural compounds like curcumin and baicalein have shown potential in fighting GBC by targeting crucial signaling pathways.
- Specific lncRNAs can serve as biomarkers for diagnosing and predicting GBC, and targeting these lncRNAs holds promise for improving treatment outcomes and reducing resistance to therapies.
Dysregulated Expression of Long Non-Coding RNA MINCR and EZH2 in Colorectal Cancer.
Iran Biomed J
January 2022
Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Background: As critical regulators, lncRNAs have attracted attention from researchers for diagnostic, prognostic, and therapeutic purposes in human carcinogenesis via interfering with mRNAs such as EZH2. Nevertheless, the potent roles and molecular mechanisms of these RNAs in CRC are not clearly known.
Methods: In this study, the tissue expressions of lncRNA MINCR and EZH2 mRNA between colorectal tumors and polyps were compared with the adjacent normal tissues collected from 114 Iranian patients, using real-time PCR method.
Long non-coding RNA MINCR promotes gallbladder cancer progression through stimulating EZH2 expression.
Cancer Lett
September 2016
Department of General Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200000, China. Electronic address:
The regulation of MYC-regulated long non-coding RNAs has been reported to contribute to certain types of cancers. However, the role of MYC-induced long non-coding RNA (MINCR) in the tumorigenesis of gallbladder cancer (GBC) is still largely unknown. In this study, we discovered that MINCR was markedly upregulated in GBC tissues compared with adjacent normal tissues.
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