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Depressive symptom profiles predict dementia onset and brain pathology in older persons. The AGES-Reykjavik study. | LitMetric

Depressive symptom profiles predict dementia onset and brain pathology in older persons. The AGES-Reykjavik study.

Neurobiol Aging

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands; National Institute on Aging, Laboratory for Epidemiology and Population Sciences, Bethesda, MD, USA.

Published: March 2022

AI Article Synopsis

  • Late-life depression (LLD) can lead to a higher risk of dementia and brain changes, but this link may depend on specific symptom types of LLD.
  • In a study of 4,354 older adults, researchers identified five LLD symptom profiles and found that severe LLD, mild LLD, and apathy increased the risk of dementia over 12 years compared to those with no LLD.
  • While only severe LLD showed increased white matter lesions over time, these changes were found to partly explain how mild LLD is related to the risk of dementia, suggesting that hippocampal atrophy and LLD are separate factors in dementia risk.

Article Abstract

Late-life depression (LLD) increases risk for dementia and brain pathology, but possibly this is only true for one or more symptom profiles of LLD. In 4354 participants (76 ± 5 years; 58% female) from the Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study, we identified five LLD symptom profiles, based on the Geriatric Depression Scale-15 (no LLD (57%); apathy (31%); apathy with emptiness (2%), mild LLD (8%) and severe LLD (2%)). Cox regression analyses showed that severe LLD, mild LLD and apathy increased risk of dementia up to 12 years, compared to no LLD. Additionally, hippocampal volume loss and white matter lesion increase, were assessed on 1.5 T MR images, at baseline and after 5 years follow-up. Only severe LLD showed increased WML volume over time, but not on hippocampal volume loss. WML increase over time mediated partially the relation between mild LLD and dementia but not for the other symptom profiles. It appears that hippocampal atrophy and LLD are independent predictors for dementia incidence, whereas for mild LLD the risk for dementia is partially mediated by WML changes.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11095503PMC
http://dx.doi.org/10.1016/j.neurobiolaging.2021.09.025DOI Listing

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