AI Article Synopsis
- - A study of the plant Agrimonia pilosa revealed two new nortriterpenoids, referred to as agrimonorterpenes A and B, along with one known triterpenoid and seven known sesquiterpenoids.
- - The structures of the new compounds were identified using advanced techniques like UV, IR, HR-ESI-MS, and NMR, with one compound uniquely featuring a five-membered A-ring.
- - The known compound, fupenzic acid, showed selective cytotoxic effects against various cancer cell lines, indicating potential therapeutic applications.
Article Abstract
A phytochemistry of the whole plant of Agrimonia pilosa led to the discovery of two new nortriterpenoids, agrimonorterpenes A and B (1 and 2), together with one known triterpenoid fupenzic acid (3) and seven known sesquiterpenoids (4-10). The new structures were determined as 19α-hydroxy-2-oxo-nor-A (3)-urs-11,12-dien-28-oic acid (1) and 2, 19β-dihydroxy-3-oxo-23-noroleana-1, 4, 12-trien-28-oic acid (2) by the spectroscopic data of UV, IR, HR-ESI-MS, and NMR. Notably, the structure of 1 possessed a rare five-membered A- ring. And this is the first time to discover the sesquiterpenoids (4-10) from A. pilosa. Compound 3 displayed the selective cytotoxicity against HCT116, BGC823, and HepG2 cell lines with the IC values of 16.31 μM, 21.94 μM, and 23.40 μM, respectively.
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| http://dx.doi.org/10.1016/j.fitote.2021.105104 | DOI Listing |
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