AI Article Synopsis
- Restoration of functional connectivity is essential for recovery after stroke, and the study examines how reactive astrocytes influence this recovery.
- Using MRI and behavioral tests in mice with modified reactive gliosis, the researchers found that these mice had poorer functional recovery and abnormal neuronal connectivity post-stroke.
- The study concludes that reactive astrocytes play a key role in promoting beneficial plasticity responses after an ischemic stroke, affecting overall recovery outcomes.
Article Abstract
Restoration of functional connectivity is a major contributor to functional recovery after stroke. We investigated the role of reactive astrocytes in functional connectivity and recovery after photothrombotic stroke in mice with attenuated reactive gliosis (GFAPVim). Infarct volume and longitudinal functional connectivity changes were determined by in vivo T2-weighted magnetic resonance imaging (MRI) and resting-state functional MRI. Sensorimotor function was assessed with behavioral tests, and glial and neural plasticity responses were quantified in the peri-infarct region. Four weeks after stroke, GFAPVim mice showed impaired recovery of sensorimotor function and aberrant restoration of global neuronal connectivity. These mice also exhibited maladaptive plasticity responses, shown by higher number of lost and newly formed functional connections between primary and secondary targets of cortical stroke regions and increased peri-infarct expression of the axonal plasticity marker Gap43. We conclude that reactive astrocytes modulate recovery-promoting plasticity responses after ischemic stroke.
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| http://dx.doi.org/10.1016/j.pneurobio.2021.102199 | DOI Listing |
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