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Reply to: Rewiring Brains in Parkinson's Disease: The New Era of Brain Stimulation.
Mov Disord
December 2021
Department of Medicine, University of Perugia, Perugia, Italy.
Schwann cells are key players in neuro-regeneration: They sense "alarm" signals released by degenerating nerve terminals and differentiate toward a proregenerative phenotype, with phagocytosis of nerve debris and nerve guidance. At the murine neuromuscular junction, hydrogen peroxide (HO) is a key signal of Schwann cells' activation in response to a variety of nerve injuries. Here we report that Schwann cells exposed to low doses of HO rewire the expression of several RNAs at both transcriptional and translational levels.
View Article and Find Full Text PDFReply to Hogan: Direct evidence of RNA-protein interactions and rewiring.
Proc Natl Acad Sci U S A
December 2017
Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 54706
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