Background: Potential hazards of fine particulate matter (PM) constituents on preterm birth (PTB) have rarely been explored in China.

Objective: To quantify the associations of PM constituents with PTB.

Methods: This study was based on a nationwide cohort of 3,723,169 live singleton births delivered between January 2010 and December 2015 in China. We applied satellite-based estimates of 5 PM constituents (organic carbon; black carbon; sulfate; ammonium; and nitrate). We used Cox proportional hazards regression models adjusted for individual covariates, temperature, humidity, and seasonality to evaluate the associations.

Results: During the entire pregnancy, each interquartile range (29 μg/m) increase in PM concentrations was associated with a 7% increase in PTB risk [hazard ratio (HR): 1.07; 95% confidence interval (CI): 1.07-1.08). We observed the largest effect estimates on carbonaceous components (HR: 1.09; 95% CI: 1.08-1.10 for organic carbon and black carbon). Early pregnancy appeared to be the critical exposure window for most constituents. Women who were older, exposed to second-hand smoke, overweight or obese before pregnancy, conceived during winter, and living in northern China or rural areas were more susceptible.

Conclusions: Carbonaceous components of PM were associated with higher PTB risk. Findings on characteristics of vulnerability underlined targeted protections on susceptible subgroups.

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http://dx.doi.org/10.1016/j.jhazmat.2021.127645DOI Listing

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