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Prognostic value of circulating calprotectin levels on the clinical course of COVID-19 differs between serum, heparin, EDTA and citrate sample types. | LitMetric

Prognostic value of circulating calprotectin levels on the clinical course of COVID-19 differs between serum, heparin, EDTA and citrate sample types.

Clin Chim Acta

Department of Laboratory Medicine, OLV Hospital, Aalst, Belgium; Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium. Electronic address:

Published: January 2022

AI Article Synopsis

  • The study investigated the use of circulating calprotectin (cCLP) as a biomarker to predict the severity of COVID-19, comparing it to other established biomarkers like IL-6 and CRP.
  • Higher levels of cCLP were found in COVID-19 patients, especially those with severe conditions, ICU admissions, and those requiring mechanical ventilation, but it did not correlate with patients who died within 30 days.
  • The results suggest that measuring cCLP can be useful for predicting the clinical progression of COVID-19, with EDTA and citrate plasma cCLP showing better discriminatory power than heparin plasma levels.

Article Abstract

Introduction: During the recent SARS-CoV-2 pandemic, circulating calprotectin (cCLP) gained interest as biomarker to predict the severity of COVID-19. We aimed to investigate the prognostic value of cCLP measured in serum, heparin, EDTA and citrate plasma.

Materials And Methods: COVID-19 patients were prospectively included, in parallel with two SARS-CoV-2 negative control populations. The prognostic value of cCLP was compared with IL-6, CRP, LDH, procalcitonin, and the 4C-mortality score by AUROC analysis.

Results: For the 136 COVID-19 patients, cCLP levels were higher compared to the respective control populations, with significantly higher cCLP levels in serum and heparin than in EDTA or citrate. Higher cCLP levels were obtained for COVID-19 patients with i) severe/critical illness (n = 70), ii) ICU admission (n = 66) and iii) need for mechanical ventilation/ECMO (n = 25), but iv) not in patients who deceased within 30 days (n = 41). The highest discriminatory power (AUC [95% CI]) for each defined outcome was i) CRP (0.835 [0.755-0.914]); ii) EDTA cCLP (0.780 [0.688-0.873]); iii) EDTA cCLP (0.842 [0.758-0.925]) and iv) the 4C-mortality score (0.713 [0.608-0.818]).

Conclusion: Measuring cCLP in COVID-19 patients helps the clinician to predict the clinical course of COVID-19. The discriminatory power of EDTA and citrate plasma cCLP levels often outperforms heparin plasma cCLP levels.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669946PMC
http://dx.doi.org/10.1016/j.cca.2021.12.011DOI Listing

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