Early DNA damage detection and cellular autophagy as drivers of stress-adaptive HS production: A paradox resolved.

Cell Chem Biol

Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA.

Published: December 2021

Appropriately responding and adapting to genotoxic, oxidative, and metabolic stress is essential for survival and is at the heart of maintaining homeostasis. In this issue of Cell Chemical Biology, Jiang et al. (2021) describe an autophagy-dependent mechanism for cytoprotective HS generation initiated by DNA damage and other small molecule treatments.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8988164PMC
http://dx.doi.org/10.1016/j.chembiol.2021.11.007DOI Listing

Publication Analysis

Top Keywords

dna damage
8
early dna
4
damage detection
4
detection cellular
4
cellular autophagy
4
autophagy drivers
4
drivers stress-adaptive
4
stress-adaptive production
4
production paradox
4
paradox resolved
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!