Cutibacterium acnes plays roles in both acne disease and healthy skin ecosystem. We observed that mutations in the tir-1/SARM1 and p38 MAPK cascade genes significantly shortened Caenorhabditis elegans lifespan upon C. acnes SK137 infection. Antimicrobial molecules were induced by SK137 in a TIR-1-dependent manner. These results suggest that defense responses against SK137 involve the TIR-1-p38 MAPK pathway in C. elegans.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8866249 | PMC |
| http://dx.doi.org/10.1093/bbb/zbab218 | DOI Listing |
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