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Effects of Fecal Sewage and Antibiotic Exposure Stress on the Intestinal Microflora of Weaned Tibetan Piglets.
Microb Pathog
January 2025
Animal Science College, Tibet Agriculture & Animal Husbandry University, Linzhi, 860000, China; The Provincial and Ministerial Co-founded Collaborative Innovation Center for R & D in Tibet Characteristic Agricultural and Animal Husbandry Resources, Linzhi 860000, China. Electronic address:
Unregulated pig farming practices expose pigs to fecal sewage and antibiotic stress, which are common health risk factors. Thus, its effects on the animals' intestinal microflora were investigated herein. In total, 2,315,563 high-quality sequences were obtained via amplitude sequencing and, after OUT clustering, the fecal sewage group was identified to have the highest number and the antibiotic exposure group the lowest.
View Article and Find Full Text PDFThe Impact of Storage Conditions on Stool Smellprints as Assessed by an Electronic Nose.
ACS Sens
January 2025
Department of Surgery, Division of Pediatric Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States.
Necrotizing enterocolitis (NEC) is a devastating disease of the neonatal gastrointestinal tract. Volatile organic compounds (VOCs), odoriferous compounds released as a byproduct of bacterial metabolism, can be used as a proxy for gut health. We hypothesized that patients with NEC would have different microbial profiles and elicit different VOC signatures as assessed by gas chromatography/mass spectrometry (GC/MS) or an electronic nose compared to controls.
View Article and Find Full Text PDFcolonization is not mediated by bile salts and utilizes Stickland fermentation of proline in an model.
mSphere
January 2025
Department of Food Science and Technology and Nebraska Food for Health Center, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
Treatment with antibiotics is a major risk factor for infection, likely due to depletion of the gastrointestinal microbiota. Two microbiota-mediated mechanisms thought to limit colonization include the conversion of conjugated primary bile salts into secondary bile salts toxic to growth and competition between the microbiota and for limiting nutrients. Using a continuous flow model that simulates the nutrient conditions of the distal colon, we investigated how treatment with 6 clinically used antibiotics influenced susceptibility to infection in 12 different microbial communities cultivated from healthy individuals.
View Article and Find Full Text PDFSynergistic and off-target effects of bacteriocins in a simplified human intestinal microbiome: implications for infection control.
Gut Microbes
December 2025
APC Microbiome Ireland, University College Cork, Cork, Ireland.
is a major cause of nosocomial diarrhea. As current antibiotic treatment failures and recurrence of infections are highly frequent, alternative strategies are needed for the treatment of this disease. This study explores the use of bacteriocins, specifically lacticin 3147 and pediocin PA-1, which have reported inhibitory activity against .
View Article and Find Full Text PDFGut Microbiome and Metabolite Characteristics Associated With Different Clinical Stages in Non-Small Cell Lung Cancer Patients.
Cancer Manag Res
January 2025
Lung Cancer Center, West China Hospital, Sichuan University, Chengdu, People's Republic of China.
Objective: Our research has pinpointed the gut microbiome's role in the progression of various pathological types of non-small cell lung cancer (NSCLC). Nonetheless, the characteristics of the gut microbiome and its metabolites across different clinical stages of NSCLC are yet to be fully understood. The current study seeks to explore the distinctive gut flora and metabolite profiles of NSCLC patients across varying TNM stages.
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