Upregulates to Inhibit IFN-γ Expression and Promote T Cell Apoptosis in Neurosyphilis.

Long non-coding RNAs are involved in many infectious diseases. Our previous studies showed that expression is increased in T lymphocytes of neurosyphilis patients compared to healthy controls. However, whether has biological functions remains unclear. The current study was undertaken to understand the mechanism of in T lymphocyte function in neurosyphilis patients. The pull-down assay showed that acted on the acetylase NAT10. The chromatin immunoprecipitation (ChIP)-PCR results showed that promoted the acetylation of histone H3K27 adjacent to the Kank1 promoter, thereby promoting Kank1 protein expression. Kank1 promotes 14-3-3 protein expression, inhibits NF-kB activation, inhibits IFN-γ secretion by T lymphocytes, and promotes T lymphocyte apoptosis. Taken together, our findings suggest a novel mechanism that upregulates to inhibit IFN-γ expression and promote T cell apoptosis in neurosyphilis.