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IgG4-related disease: lessons from the first 20 years.
Rheumatology (Oxford)
March 2025
Harvard Medical School, Division of Rheumatology, Allergy, and Immunology, The Edward A. Fox Chair in Medicine, Massachusetts General Hospital, Executive Chairman, The IgG4ward! Foundation, Boston, MA, USA.
Immunoglobulin G4-related disease (IgG4-RD) is a systemic immune-mediated fibroinflammatory disease that is believed but not confirmed to have an autoimmune origin. Since its discovery nearly two decades ago, our understanding of its pathophysiology and clinical manifestations has grown substantially. Early diagnosis and treatment of this elusive disease can prevent substantial organ damage from end-stage fibrosis.
View Article and Find Full Text PDFKnowledge map and emerging trends of oxidative stress in wound healing: A bibliometric analysis from 2000 to 2023.
Medicine (Baltimore)
March 2025
Department of Otolaryngology, Head, Neck and Plastic Surgery, Honghui Hospital, Xi'an Jiaotong University, Xian, China.
The skin's integrity is vulnerable to external elements that can induce injuries, leading to wound formation. It's crucial to comprehend wound healing processes to protect the body when this protective barrier is compromised. Over the last 2 decades, there has been considerable progress in understanding delayed wound healing, with a focus on the mechanisms and microenvironmental factors involved.
View Article and Find Full Text PDFThe Role of Gluten in the Development of Autoimmune Thyroid Diseases: A Narrative Review.
Int J Endocrinol Metab
July 2024
Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Context: In recent decades, adverse reactions to gluten have increased, collectively known as gluten-related disorders (GRDs). The most prominent GRD is celiac disease (CD), a T-cell-mediated autoimmune-like disorder of the small intestine triggered by the ingestion of gluten proteins in genetically predisposed individuals. Celiac disease is often associated with various autoimmune and idiopathic conditions, including autoimmune thyroid disorders (AITDs).
View Article and Find Full Text PDFImmunotoxicity of thyroid hormone system disrupting compounds in fish.
Aquat Toxicol
March 2025
Vrije Universiteit Amsterdam, Amsterdam Institute for Life and Environment, Section Environmental Health & Toxicology, De Boelelaan 1085, Amsterdam 1081 HV, the Netherlands. Electronic address:
Endocrine disrupting compounds (EDCs) are among the most studied environmental pollutants in the field of (eco)toxicology, and different fish species are commonly used as model organisms, especially for studying reprotoxic effects. Despite the scientific and regulatory importance of EDCs, little attention has been given to their immunotoxic effects in fish. Basic knowledge and test systems for immune-related outcomes in fish are limited.
View Article and Find Full Text PDFAn international consensus on the etiology, risk factors, diagnosis and Management for individuals with Frozen Shoulder: a Delphi study.
J Man Manip Ther
March 2025
Bognor War Memorial Hospital, Sussex Community NHS Foundation Trust, Bogner Regis, UK.
Introduction: There has been an emergence of evidence in the area of frozen shoulder (FS) within the past decade related to risk factors, etiology, diagnosis, and management. It has become increasingly challenging for clinicians and researchers to stay up to date in these areas, particularly with the clinical practice guidelines that are available being few and outdated. To this end, the aim of this study was to produce an international consensus on the risk factors, etiology, diagnosis and management for individuals with FS.
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