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Nano-viscosimetry analysis of membrane disrupting peptide magainin2 interactions with model membranes.
Biophys Chem
January 2025
La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Australia. Electronic address:
The rapid spread of antibiotic-resistant strains of bacteria has created an urgent need for new alternative antibiotic agents. Membrane disrupting antimicrobial peptides (AMPs): short amino acid sequences with bactericidal and fungicidal activity that kill pathogens by permeabilizing their plasma membrane may offer a solution for this global health crisis. Magainin 2 is an AMP secreted by the African clawed frog (Xenopus laevis) that is described as a toroidal pore former membrane disrupting AMP.
View Article and Find Full Text PDFUsing the Radial Distribution Function to Analyze Atomic Force Microscopy Images of Colloidal Systems.
Int J Mol Sci
December 2024
Institute of Biomedical Chemistry, Pogodinskaya Str., 10, Moscow 119121, Russia.
Biomacromolecules generally exist and function in aqueous media. Is it possible to estimate the state and properties of molecules in an initial three-dimensional colloidal solution based on the structure properties of biomolecules adsorbed on the two-dimensional surface? Using atomic force microscopy to study nanosized objects requires their immobilization on a surface. Particles undergoing Brownian motion in a solution significantly reduce their velocity near the surface and become completely immobilized upon drying.
View Article and Find Full Text PDFQualitative Research of Composite Graphene Membranes Using the Electric Mode in SEM and AFM.
Materials (Basel)
January 2025
Faculty of Mechanical Engineering, Institute of Materials Science and Engineering, Lodz University of Technology, 1/15 Stefanowskiego St., 90-924 Lodz, Poland.
The development of new graphene-based materials necessitates the application of suitable material imaging techniques, especially for the identification of defects in the graphene structure and its continuity. For this purpose, it is natural to use one of the main properties of graphene-electrical conductivity. In this work, we prepare a 9 cm large-area monolayer graphene membrane on porous scaffolding sealed with either GO or rGO.
View Article and Find Full Text PDFSurface Hydrophilic Modification of Polypropylene by Nanosecond Pulsed Ar/O Dielectric Barrier Discharge.
Materials (Basel)
December 2024
College of Electrical Engineering and Control Science, Nanjing Tech University, Nanjing 211816, China.
Polypropylene (PP) membranes have found diverse applications, such as in wastewater treatment, lithium-ion batteries, and pharmaceuticals, due to their low cost, excellent mechanical properties, thermal stability, and chemical resistance. However, the intrinsic hydrophobicity of PP materials leads to membrane fouling and filtration flux reduction, which greatly hinders the applications of PP membranes. Dielectric barrier discharge (DBD) is an effective technique for surface modification of materials because it generates a large area of low-temperature plasma at atmospheric pressure.
View Article and Find Full Text PDFImaging the Ultrastructure of Isolated Peptidoglycan Sacculi from Rod-Shaped J99 Cells by Atomic Force Microscopy.
Molecules
January 2025
Institute of Pharmaceutical Biology and Phytochemistry, University of Münster, 48149 Münster, Germany.
Peptidoglycan is the basic structural polymer of the bacterial cell wall and maintains the shape and integrity of single cells. Despite years of research conducted on peptidoglycan's chemical composition, the microscopic elucidation of its nanoscopic architecture still needs to be addressed more thoroughly to advance knowledge on bacterial physiology. Apart from the model organism , ultrastructural imaging data on the murein architecture of Gram-negative bacteria is mostly missing today.
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