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Effect of nirmatrelvir/ritonavir (Paxlovid) on hospitalization among adults with COVID-19: An electronic health record-based target trial emulation from N3C.
PLoS Med
January 2025
University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Background: Nirmatrelvir with ritonavir (Paxlovid) is indicated for patients with Coronavirus Disease 2019 (COVID-19) who are at risk for progression to severe disease due to the presence of one or more risk factors. Millions of treatment courses have been prescribed in the United States alone. Paxlovid was highly effective at preventing hospitalization and death in clinical trials.
View Article and Find Full Text PDFBurden of death associated with SARS-CoV-2 infection during the pandemic in Flint, Michigan (MI), mortality trends over the 2-year period: impact of social and health inequities.
Antimicrob Steward Healthc Epidemiol
August 2024
Department of Medicine, Hurley Medical Center, Flint, MI, USA.
Background: This cross-sectional study aims to determine the mortality trends in patients with SARS-CoV-2 infection during the pandemic in Flint, MI.
Methods: Records from 1,663 consecutive adult patients (≥18 years of age) with confirmed SARS-CoV-2 infection, admitted and discharged from our facility from 03/2020 through 02/2022, were abstracted and analyzed. Multivariable logistic regression analysis was performed to examine the association between study explanatory variables (ie, sex, age, co-morbidities, etc.
The effect of coronavirus disease 2019 vaccination on pregnant women: A scoping review.
Health SA
December 2024
Department of Nursing Science, Faculty of Health Science, University of Pretoria, Pretoria, South Africa.
Background: Globally, reports have shown that pregnant women refuse to receive the coronavirus disease 2019 (COVID-19) vaccine. This has posed a significant concern given the global impact of the COVID-19 pandemic.
Aim: This study aims to explore the current evidence on the effect of COVID-19 vaccination on pregnant women.
Determinants of COVID-19 vaccination coverage in European and Organisation for Economic Co-operation and Development (OECD) countries.
Front Public Health
January 2025
Centre for Health Economics Research and Modelling Infectious Diseases, Vaccine and Infectious Disease Institute, University of Antwerp, Antwerp, Belgium.
Introduction: In relatively wealthy countries, substantial between-country variability in COVID-19 vaccination coverage occurred. We aimed to identify influential national-level determinants of COVID-19 vaccine uptake at different COVID-19 pandemic stages in such countries.
Methods: We considered over 50 macro-level demographic, healthcare resource, disease burden, political, socio-economic, labor, cultural, life-style indicators as explanatory factors and coverage with at least one dose by June 2021, completed initial vaccination protocols by December 2021, and booster doses by June 2022 as outcomes.
Japan's Growing Public Health Crisis: Tackling the Alarming Increase in Streptococcal Toxic Shock Syndrome.
Cureus
December 2024
Gastroenterology, School of Digestive and Liver Diseases, Institute of Postgraduate Medical Education and Research, Kolkata, IND.
Japan is experiencing a dramatic spike in streptococcal toxic shock syndrome (STSS) cases, exceeding the previous year's statistics. This life-threatening illness, caused by , has been connected not only to the relaxation of COVID-19 precautions but also to the prolonged effects of confinement and lack of contact with the surrounding environment/ecology. The condition is characterized by a sudden onset of symptoms, including high fever, rash, and shock, and demands immediate medical intervention.
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