Multicore fibers (MCFs) offer a fascinating solution to the need to increase the fiber density and thus meet the exponentially growing demand for capacity in optical communication networks. Despite overwhelming research into MCFs, the desire for a general fusion splicing scheme between dissimilar MCFs remains unanswered. Here, we propose a tapering technique to reshape MCFs that includes both reverse-tapering and down-tapering schemes and can be exploited to tailor the core-to-core spacing and modify the modal property of MCFs. By matching both the spacing and the mode field diameter, we demonstrated a low-loss (0.18 ± 0.10 dB) and low-crosstalk (-68 ± 3 dB) fusion splice between two spacing-mismatched MCFs with a spacing difference of up to 26 μm. The proposed novel schemes are also suitable for splicing between MCFs with slightly different spacings and can provide a unique perspective for fabricating MCF devices and boosting various MCF applications.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1364/OL.447602 | DOI Listing |
Ann Med
December 2025
Department of Breast Surgery, Second Affiliated Hospital and Cancer Institute (Provincial Key Laboratory of Tumor Microenvironment and Immunotherapy, Key Laboratory of Cancer Prevention & Intervention, National Ministry of Education), Zhejiang University School of Medicine, Hangzhou, China.
Background: Quaking (QKI) is a member of the signal transduction and activators of RNA (STAR) family, performing a crucial multifunctional regulatory role in alternative splicing, mRNA precursor processing, mRNA transport and localization, mRNA stabilization, and translation during tumour progression. Abnormal QKI expression or fusion mutations lead to aberrant RNA and protein expression, thereby promoting tumour progression. However, in many types of tumour, QKI played a role as tumour suppressor, the regulatory role of QKI in tumour progression remains ambiguous.
View Article and Find Full Text PDFMethods Mol Biol
December 2024
Biomedical Sciences and Molecular Biology, College of Public Health, Medical & Vet Sciences, James Cook University, Douglas, QLD, Australia.
Extensive research into gene fusions in cancer and other diseases has led to the discovery of novel biomarkers and therapeutic targets. Concurrently, various bioinformatics tools have been developed for fusion detection in RNA sequencing data, which, in the age of increasing affordability of sequencing, have delivered a large-scale identification of transcriptomic abnormalities. Historically, the focus of fusion transcript research was predominantly on coding RNAs and their resultant proteins, often overlooking non-coding RNAs (ncRNAs).
View Article and Find Full Text PDFCell Death Dis
December 2024
Department of Molecular Biology of Cancer, Medical University of Lodz, 6/8 Mazowiecka Street, 92-215, Lodz, Poland.
Apoptosis-regulating proteins from the B-cell lymphoma-2 (BCL-2) family are of continued interest as they represent promising targets for anti-cancer therapies. Myeloid cell leukemia-1 (MCL-1), which usually refers to the long isoform (MCL-1L) is frequently overexpressed in various types of cancer. However, MCL1 pre-mRNA can also undergo alternative splicing through exon skipping to yield the short isoform, MCL-1S.
View Article and Find Full Text PDFExp Anim
December 2024
Deafness Project, Department of Basic Medical Sciences, Tokyo Metropolitan Institute of Medical Science.
An unconventional myosin, myosin VI gene (MYO6), contributes to recessive and dominant hearing loss in humans and mice. The Kumamoto shaker/waltzer (ksv) mouse is a model of deafness resulting from a splice-site mutation in Myo6. While ksv/ksv homozygous mice are deaf due to cochlear hair cell stereocilia fusion at the neonatal stage, the hearing phenotypes of ksv/+ heterozygous mice have been less clear.
View Article and Find Full Text PDFNucleic Acids Res
December 2024
Azrieli Faculty of Medicine, Bar Ilan University, Henrieta Szold 8, Safed, 1311502, Israel.
Gene fusions are nucleotide sequences formed due to errors in replication and transcription control. These errors, resulting from chromosomal translocation, transcriptional errors or trans-splicing, vary from cell to cell. The identification of fusions has become critical as key biomarkers for disease diagnosis and therapy in various cancers, significantly influencing modern medicine.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!