Francis Pasche was a French Psychiatrist and Psychoanalyst. He is known for his research on genesis and specificities of psychoses. He also developed some original views on anti-narcissism.
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Francis Pasche.
Int J Psychoanal
February 2022
Training and Supervising Psychoanalyst, Paris Psychoanalytical Society, Sucy en Brie, France.
Francis Pasche was a French Psychiatrist and Psychoanalyst. He is known for his research on genesis and specificities of psychoses. He also developed some original views on anti-narcissism.
View Article and Find Full Text PDFIn 2012 several articles reported interesting findings for the ambulatory practice in internal general medicine. A negative rapid test for influenza does not rule out that diagnosis. A test assessing the walking speed in the elderly can help determining who would benefit from antihypertensive therapy.
View Article and Find Full Text PDFStructural changes in platelet glycoprotein IIb/IIIa by plasmin: determinants and functional consequences.
Blood
January 1994
Cardiology Divisions, Brigham and Women's Hospital, Boston, MA 02115.
Plasmin exposure modulates platelet aggregation responses, but a direct effect of plasmin on the platelet fibrinogen receptor, glycoprotein IIb/IIIa (GPIIb/IIIa), has never been conclusively shown in a plasma milieu. To examine this issue, we incubated platelets in platelet-rich plasma with plasmin and measured the effect of this treatment on platelet aggregation, fibrinogen binding, and the structural integrity of GPIIb/IIIa. Plasmin treatment reduced maximal reversible fibrinogen binding in a dose-dependent fashion, and this reduction in binding was accompanied by a correlative reduction in the maximal rate of aggregation.
View Article and Find Full Text PDFPlatelets and fibrinolysis.
Platelets
October 2012
Cardiology Divisions, Brigham and Women's Hospital and Brockton/West Roxbury VA Medical Center, Harvard Medical School, 75 Francis Street, Boston, Massachusetts, 02115, USA.
Thrombolytic therapy has galned increasing acceptance in the clinical arena in recent years, but is fraught with three primary problems: delays in time to lysis, reocclusion, and haemorrhage. Inasmuch as the platelet is a critical determinant of thrombosis and, at the same time, interacts with molecular elements important in fibrinolysis, this anuclear cell plays a central role in the outcome of thrombolytic therapy. Platelet-rich thrombi are less sensitive to thrombolysis than platelet-poor thrombi, and reocclusive thrombi are richer in platelets than are thrombi that form de novo.
View Article and Find Full Text PDF1. Freud's study of Mourning and Melancholia provides the psychopathological model for depression. Basing himself upon the views of Abraham regarding the oral sadism which the depressed person wants to inflict upon the lost object.
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